CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(9), С. 10998 - 11007

Опубликована: Апрель 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Язык: Английский

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Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing

Small, Год журнала: 2024, Номер 20(45)

Опубликована: Июль 25, 2024

Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.

Язык: Английский

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Insights into ocular therapeutics: A comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105785 - 105785

Опубликована: Май 15, 2024

Язык: Английский

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Isolation, structural characterization of (1→4), (1→6)-α-D-glucan from Dioscorea Alata and Synthesis and catalytic activity studies of (1→4), (1→6)-α-D-glucan derived carbon dots

Carbohydrate Research, Год журнала: 2025, Номер 549, С. 109383 - 109383

Опубликована: Янв. 11, 2025

Язык: Английский

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Iron‐doped nanozymes with spontaneous peroxidase‐mimic activity as a promising antibacterial therapy for bacterial keratitis

Smart Medicine, Год журнала: 2024, Номер 3(2)

Опубликована: Май 22, 2024

The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is great significance for the treatment bacterial keratitis. In this study, we have developed iron-doped nanozymes (Fe

Язык: Английский

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Carbon Dots as Bioactive Antifungal Nanomaterials

ChemMedChem, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Nowadays, the widespread diffusion of infections caused by opportunistic fungi represents a demanding threat for global health security. This phenomenon has also worsened emergence contagious events in hospitalisation environments and fact that many have developed harsh serious resistance mechanisms to traditional antimycotic drugs. Hence, design novel antifungal agents is key factor counteract mycotic resistance. Within this context, nanomaterials are gaining increasing attention thanks their biocidal character. Among these, carbon dots (CDs) represent class zero-dimensional, photoluminescent quasi-spherical nanoparticles which, great tuneable features, found applications catalysis, sensing biomedicine. Nevertheless, only few works define recapitulate properties. Therefore, we aim give an overview about recent advances synthesis CDs active against infective fungi. We described general features fungal cells, highlighting some most common mechanisms. Then, evaluated effects CDs, antimicrobial drugs-loaded CDs-incorporated packaging systems on different analysed use as fluorescent nano-trackers bioimaging, showing, all effects, promising application agents.

Язык: Английский

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Facile One‐Pot Assembly of a Versatile Photoactive Nanozyme for Highly Efficient Antibacterial Therapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

Abstract Conventional combinational antibacterial therapy requires the complicated assembly of multiple components that might cause a premature leak therapeutic agents. Thus one‐pot highly integrated multifunctional agents is desirable for treating multidrug‐resistant (MDR) bacteria. Herein, vancomycin‐derived carbon dots (Van‐CDs) are facilely developed as compact and powerful photodynamic nanozyme platform achieves augmented reactive oxygen species (ROS) generation accelerating bacterial elimination. By residual recognition groups vancomycin, red emissive Van‐CDs gain specific affinity toward bacteria with high binding constant 20 L g −1 , manifesting superior bacteria‐imaging ability. Meanwhile, encoded an excellent peroxidase‐mimicking (POD) activity mediating H 2 O ‐activated evolvement •OH, also endowed intrinsic property simultaneously producing singlet ( 1 ). Surprisingly, possesses auxiliary photothermal feature, which enables imaging‐guided hyperthermia‐reinforced in vivo. Furthermore, subcutaneous abscess model established to validate their pronounced biofilm eradication wound healing acceleration vivo through Van‐CDs‐promoted collagen deposition. Taken together, present all‐in‐one carbon‐derived functions represents promising competitive candidate diabetic infections clinical research.

Язык: Английский

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Nanomaterial-based therapeutics for enhanced antifungal therapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(37), С. 9173 - 9198

Опубликована: Янв. 1, 2024

The application of nanotechnology in antifungal therapy is gaining increasing attention. Current drugs have significant limitations, such as severe side effects, low bioavailability, and the rapid development resistance. Nanotechnology offers an innovative solution to address these issues. This review discusses three key strategies enhance efficacy. Firstly, nanomaterials can their interaction with fungal cells

Язык: Английский

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Cu²⁺-Cross-Linked Tannic Acid Carbon Dot Nanoparticles for Mold Inhibition

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Mold has long been a priority because of its potential threat to human health and reduction in the value wood. Most traditional mold inhibitors have toxic effects on environment, so developing safe nontoxic remains challenge. In this study, tannic acid carbon dots (TA-CDs) were obtained via straightforward one-step hydrothermal process. Subsequently, Cu2+ cross-linked dot nanoparticles (TA-CDs-Cu2+) synthesized by introducing TA-CDs at room temperature. The TA-CDs-Cu2+ can be firmly anchored surface Aspergillus niger spores, triggering rapid release localized acidic environment. released triggered conversion Cu+, destroying cell wall membrane structure A. reducing cellular esterase activity. addition, demonstrated diminish biomass biofilms markedly. use poplar birch wood achieved protection class 0 20 mg Cu/mL, which found exhibit unparalleled advantages as inhibitor. Meanwhile, warming effect opened up avenues for design inhibition therapeutic agents photothermal synergistic inhibition.

Язык: Английский

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Synthesis and Characterization of In Situ Chitosan/Cyclodextrin/Catechol Gel for Rapamycin Delivery

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Abstract Innovative in situ drug‐releasing hydrogels are emerging as a promising therapeutic strategy for anterior segment ocular diseases, leveraging the unique anatomy of eye. Rapamycin (RAP) is an effective immunosuppressive agent organ transplantation; however, high hydrophobicity and low bioavailability have strongly constrained its clinical application. Chitosan (CS) used backbone, RAP can be loaded through supramolecular host‐guest interactions cyclodextrin (CD) to obtain chitosan‐conjugated‐(cydodextrin with 3,4‐dihydroxyhrocinnamic acid) rapamycin (CCH/RAP) controlled drug release properties. Here, hydrogel prepared by simple amidation reaction reported. It discovered that conjugated polymers form crosslinked networks non‐covalent bonds. The design allows excellent transparency suitable pore size, which ensure it applications. Moreover, results show introduction CD effectively delays initial RAP. This pioneering work presents eco‐friendly method fabricating superior delivery capabilities, hold significant potential mitigating immune rejection following corneal transplantation.

Язык: Английский

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