Ultrasound-Responsive Nanobubbles for Breast Cancer: Synergistic Sonodynamic, Chemotherapy, and Immune Activation through the cGAS-STING Pathway

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Breast cancer remains the leading cause of cancer-related deaths among women worldwide, necessitating more effective treatment strategies. Chemotherapy combined with immunotherapy is first-line for breast cancer, but it still suffers from limited therapeutic efficiency and serious side effects, which are usually due to poor delivery efficiency, drug resistance tumor cells, immunosuppressive microenvironment. This study explores development ultrasound-responsive nanobubbles (Ce6/PTX Nbs) targeted imaging sonoimmunotherapy in treatment. By integrating sonodynamic therapy (SDT), chemotherapy, immunotherapy, aim address challenges such as delivery, systemic toxicity, immune suppression conventional therapies. The nanobubbles, composed sonosensitizer chlorin e6 (Ce6)-modified phospholipid loaded chemotherapeutic agent paclitaxel (PTX) enhancing drug-loading capacity, designed precisely target sites via cyclic-RGD peptides. Upon ultrasound activation, Ce6 induces reactive oxygen species (ROS), promoting immunogenic cell death (ICD), while PTX disrupts mitosis, response. nanobubbles' responsiveness facilitates real-time controlled release, maximizing efficacy minimizing effects. Key findings demonstrate that Ce6/PTX Nbs significantly reduced growth a 4T1 model, enhanced activation cGAS-STING pathway, increased infiltration CD8+ T cells both primary distant tumors. In combination anti-PD-L1 checkpoint inhibitors, achieved substantial metastasis. innovative approach offers highly targeted, effective, minimally toxic potential clinical translation its dual capabilities.

Язык: Английский

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Recent advances of piezoelectric materials used in sonodynamic therapy of tumor

Coordination Chemistry Reviews, Год журнала: 2024, Номер 523, С. 216282 - 216282

Опубликована: Окт. 22, 2024

Язык: Английский

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Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Язык: Английский

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Microcrystalline Bi2WO6 co-modified by oxygen vacancies and bismuth metal deposits for the efficient photocatalytic oxidation of nitric oxide

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106262 - 106262

Опубликована: Март 1, 2025

Язык: Английский

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