Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
Язык: Английский
Recent advances of piezoelectric materials used in sonodynamic therapy of tumor
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
523, С. 216282 - 216282
Опубликована: Окт. 22, 2024
Язык: Английский
Ultrasound-Responsive Nanobubbles for Breast Cancer: Synergistic Sonodynamic, Chemotherapy, and Immune Activation through the cGAS-STING Pathway
Huan Pu,
Jia Huang,
Bin Gui
и другие.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Breast
cancer
remains
the
leading
cause
of
cancer-related
deaths
among
women
worldwide,
necessitating
more
effective
treatment
strategies.
Chemotherapy
combined
with
immunotherapy
is
first-line
for
breast
cancer,
but
it
still
suffers
from
limited
therapeutic
efficiency
and
serious
side
effects,
which
are
usually
due
to
poor
delivery
efficiency,
drug
resistance
tumor
cells,
immunosuppressive
microenvironment.
This
study
explores
development
ultrasound-responsive
nanobubbles
(Ce6/PTX
Nbs)
targeted
imaging
sonoimmunotherapy
in
treatment.
By
integrating
sonodynamic
therapy
(SDT),
chemotherapy,
immunotherapy,
aim
address
challenges
such
as
delivery,
systemic
toxicity,
immune
suppression
conventional
therapies.
The
nanobubbles,
composed
sonosensitizer
chlorin
e6
(Ce6)-modified
phospholipid
loaded
chemotherapeutic
agent
paclitaxel
(PTX)
enhancing
drug-loading
capacity,
designed
precisely
target
sites
via
cyclic-RGD
peptides.
Upon
ultrasound
activation,
Ce6
induces
reactive
oxygen
species
(ROS),
promoting
immunogenic
cell
death
(ICD),
while
PTX
disrupts
mitosis,
response.
nanobubbles'
responsiveness
facilitates
real-time
controlled
release,
maximizing
efficacy
minimizing
effects.
Key
findings
demonstrate
that
Ce6/PTX
Nbs
significantly
reduced
growth
a
4T1
model,
enhanced
activation
cGAS-STING
pathway,
increased
infiltration
CD8+
T
cells
both
primary
distant
tumors.
In
combination
anti-PD-L1
checkpoint
inhibitors,
achieved
substantial
metastasis.
innovative
approach
offers
highly
targeted,
effective,
minimally
toxic
potential
clinical
translation
its
dual
capabilities.
Язык: Английский
Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis
Yang Zhu,
Dengliang Wang,
Chengzhong Du
и другие.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Abstract
Sonodynamic
therapy
(SDT)
has
emerged
as
a
promising
noninvasive
approach
for
tumor
therapy.
However,
the
effectiveness
of
traditional
inorganic
semiconductor
sonosensitizers
is
hindered
by
rapid
electron
(e
−
)
and
hole
(h
+
recombination
under
ultrasonic
(US)
stimulation,
well
hypoxic
reductive
conditions
microenvironment
(TME),
which
limit
generation
reactive
oxygen
species
(ROS).
Herein,
ruthenium
(Ru)
single‐atom
nanozyme‐driven
superimposition‐enhanced
titanium
dioxide‐based
sonosensitizer
(Ru/TiO
2‐x
SAE)
presented
that
features
sufficient
vacancies
high
e
/h
separation
efficiency.
Through
synchrotron
radiation‐based
X‐ray
absorption
spectroscopy
extended
fine
structure
analysis
it
confirmed
in
TiO
nanoparticles
promote
immobilization
single‐atomic
Ru,
forming
Ru‐O₄
active
sites.
Density
functional
theory
calculations
demonstrate
alter
electronic
nanosensitizer,
enhanced
separation,
increasing
adsorption,
accelerating
reaction
kinetics
US
ultimately
improving
ROS
production.
Moreover,
Ru/TiO
SAE
boosts
sonodynamic
efficacy
mitigating
TME.
This
attributed
to
its
catalase‐
glutathione
peroxidase
4‐like
activities,
facilitate
trigger
lipid
peroxidation‐mediated
ferroptosis.
These
findings
highlight
innovative
role
Ru
optimizing
SDT‐induced
ferroptosis,
demonstrating
potential
advancing
cancer
Язык: Английский
Microcrystalline Bi2WO6 co-modified by oxygen vacancies and bismuth metal deposits for the efficient photocatalytic oxidation of nitric oxide
Surfaces and Interfaces,
Год журнала:
2025,
Номер
unknown, С. 106262 - 106262
Опубликована: Март 1, 2025
Язык: Английский
Dual-engineered strategy of Ni-CeO nanozyme with enhanced oxidase activity for sensitive colorimetric detection of total antioxidant capacity
Talanta,
Год журнала:
2025,
Номер
unknown, С. 128307 - 128307
Опубликована: Май 1, 2025
Язык: Английский
Dual Strategy of Ca2+ Influx and Collagen Denaturation to Remodel the Extracellular Matrix and Amplify Sonopiezoelectric Therapy
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 30, 2025
Abstract
Extracellular
matrix
(ECM),
a
core
member
of
tumor
microenvironment,
is
≈1.5‐fold
harder
than
the
surrounding
normal
tissues.
Regulating
stiffness
ECM
can
significantly
impact
physiological
activities
cells,
such
as
growth,
differentiation,
and
migration.
Herein,
sonopiezoelectric‐response
nanoplatform
consisting
Cu
3
BiS
nanospheres
(CBS
NSs)
constructed
for
remodeling.
Sonopiezoelectric
therapy
(SPT)
chemodynamic
(CDT)
are
conducted
using
ultrasound
(US)
near‐infrared
irradiation.
Under
US
irradiation,
mechanical
strain
CBS
NSs
causes
piezoelectric
polarization
promotes
redox
reaction
through
energy
band
bending.
The
built‐in
electric
field
generated
by
irradiation
amplifies
efficiency
Fenton‐like
substantially
enhances
reactive
oxygen
species
production.
Moreover,
property‐mediated
electrical
signals
allow
Ca
2+
influx,
upregulating
levels
metalloproteinase
(MMP)‐2
MMP‐9.
Integrating
with
generates
localized
heat,
which
effectively
denature
collagen,
reduce
stiffness,
enhance
permeability
into
solid
tumors,
thus
improving
SPT
effect.
combination
MMP
upregulation
collagen
degradation
maximize
benefits
remodeling
synergistically
cancer
therapeutic
efficacy
SPT/CDT.
This
SPT/CDT
synergistic
platform
an
innovative
strategy
therapy.
Язык: Английский