Cancers, Год журнала: 2025, Номер 17(7), С. 1211 - 1211

Опубликована: Апрель 2, 2025

Glioblastoma (GBM) remains a challenging cancer to treat with limited effective therapies. Standard treatments, including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, offer marginal survival benefits but are often by side effects drug resistance. Temozolomide is the most commonly used chemotherapy; however, resistance lack of efficacy in recurrent GBM hinder its success. Tumor treating fields (TTFields), novel non-invasive modality that utilizes alternating electric fields, have recently emerged as promising treatment for GBM. TTFields work disrupting function mitotic spindle inducing apoptosis cells. They can be especially when combined other enhance delivery paired chemotherapy increasing permeability blood-brain barrier cell membranes, leading more tumor inhibition. Similarly, increase sensitivity radiation therapy improve therapies, such sorafenib particularly extra-cranial tumors. The Optune device, primary medical device TTFields' delivery, offers convenient versatile option, allowing remote care exhibiting fewer adverse effects. This review discusses potential valuable addition treatment, combination highlights device's clinical applications.

Язык: Английский