The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
86(1), С. 1012 - 1022
Опубликована: Дек. 10, 2020
A
blue-light-emitting
diode
(LED)
promoted
coupling
of
aryl
diazoacetates
with
sulfur
ylides
is
described.
This
protocol
features
mild
conditions,
good
functional
group
tolerance,
and
broad
substrate
scope
for
both
ylides.
Under
optimal
reaction
a
wide
range
trisubstituted
olefins
obtained
in
moderate
to
yield,
which
can
be
further
transferred
other
biologically
important
heterocycles
after
two-step
simple
operation.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(6), С. 4415 - 4423
Опубликована: Март 2, 2022
An
efficient
synthesis
of
a
variety
[1,2,3]triazolo-[1,5-a]quinoxalin-4(5H)-ones
via
[3
+
2]
cyclization
reaction
by
photoredox
catalysis
between
quinoxalinones
and
hypervalent
iodine(III)
reagents
is
reported.
A
range
were
tolerated
well.
This
allows
access
to
structurally
diverse
in
moderate
good
yields.
ACS Catalysis,
Год журнала:
2022,
Номер
12(24), С. 15707 - 15714
Опубликована: Дек. 7, 2022
The
rapid
incorporation
of
alkyl
and
acyl
groups
into
C–H
bonds
N-heterocycles
is
in
demand
for
the
development
lead
candidates
drug
discovery.
Herein,
we
report
cobalt(II)-catalyzed
alkylation
acylation
with
1,4-dihydropyridines
(DHPs)
as
alkylating
acylating
agents.
Notably,
a
combination
KBrO3
Co(II)
catalyst
was
successfully
employed
generation
radicals
from
DHPs.
A
series
heterocycles,
including
azauracils,
quinoxalinones,
pyrazinones,
pyridones,
quinolones,
quinazolinones,
xanthines,
chromones,
azine
N-oxides,
were
compatible
under
developed
conditions.
applicability
protocol
challenging
contexts
highlighted
by
selective
modification
well
gram-scale
synthesis
bioactive
molecules.
Combined
mechanistic
investigations
aided
elucidation
plausible
reaction
mechanism.
Organic Letters,
Год журнала:
2023,
Номер
25(22), С. 4113 - 4118
Опубликована: Май 30, 2023
A
photoredox-catalyzed
1,2-amidoheteroarylation
of
unactivated
alkenes
with
O-acyl
hydroxylamine
derivatives
and
heterocycles
is
presented.
range
heterocycles,
including
quinoxaline-2(1H)-ones,
azauracils,
chromones,
quinolones,
are
capable
for
this
process,
allowing
the
direct
synthesis
valuable
heteroarylethylamine
derivatives.
Structurally
diverse
reaction
substrates,
drug-based
scaffolds,
were
successfully
applied,
demonstrating
practicality
method.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(5), С. 687 - 692
Опубликована: Фев. 8, 2023
Abstract
An
iron(II)‐catalyzed
three‐component
reaction
was
developed
for
the
construction
of
trichloromethylated
3‐benzylquinoxalin‐2(1
H
)‐ones.
This
conducted
through
trichloromethylation
alkenes
with
quinoxalin‐2(1
)‐ones
using
commercially
available
chloroform
as
trichloromethyl
radical
source,
which
provided
a
convenient
approach
toward
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
86(1), С. 1012 - 1022
Опубликована: Дек. 10, 2020
A
blue-light-emitting
diode
(LED)
promoted
coupling
of
aryl
diazoacetates
with
sulfur
ylides
is
described.
This
protocol
features
mild
conditions,
good
functional
group
tolerance,
and
broad
substrate
scope
for
both
ylides.
Under
optimal
reaction
a
wide
range
trisubstituted
olefins
obtained
in
moderate
to
yield,
which
can
be
further
transferred
other
biologically
important
heterocycles
after
two-step
simple
operation.
