Synthesis,
Год журнала:
2024,
Номер
56(12), С. 1932 - 1940
Опубликована: Янв. 9, 2024
Abstract
A
simple
and
efficient
method
for
the
synthesis
of
1,4-dihydropyridines
from
amines,
N,N-dimethyl
enaminone
N,N-dimethylaminoethanol
in
a
four-component
[2+1+2+1]
annulation
catalyzed
by
FeCl3
has
been
established,
where
was
applied
as
methine
source.
The
procedure
executed
smoothly,
resulting
wide
range
with
moderate
to
good
yields.
Additionally,
these
fluorophores
exhibited
photophysical
characteristics.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(26), С. 5475 - 5480
Опубликована: Янв. 1, 2023
An
Fe-mediated
four-component
reaction
of
enaminones,
anhydrides
and
tetrahydrofuran
through
a
cascade
[1
+
2
3]-cyclization/esterification
process
is
presented.
This
protocol
provides
new
effective
method
to
construct
4-alkylated
1,4-dihydropyridines
with
an
ester
fragment.
Cyclic
ether
employed
as
the
C4
source
for
first
time.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(21), С. 15568 - 15576
Опубликована: Окт. 14, 2021
A
transition-metal-free
methodology
employing
nitroenynes
and
enaminones
has
been
developed
to
access
3-alkynylpyrrole
derivatives.
This
mild
cyclization
reaction
might
proceed
through
the
nucleophilic
addition,
intramolecular
cyclization,
subsequent
elimination
processes.
The
protocol
features
a
broad
substrate
scope,
good
selectivity,
functional
group
tolerance.
Notably,
advantage
of
this
method
is
also
highlighted
by
controlled
reduction
generate
alkenyl-
or
alkylpyrrole
derivatives
in
excellent
yields.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
88(21), С. 15444 - 15451
Опубликована: Сен. 13, 2022
Tetrabutylammonium
acetate
(TBAA)
and
Cu(OAc)2
worked
as
a
binary
catalytic
system
for
the
solvent-free
N-formylation
of
amines
with
CO2
PhSiH3.
This
catalysis
making
C-H
C-N
bonds
was
coupled
C-C
bond-forming
reactions
to
achieve
one-pot
synthesis
enamines,
aldehydes,
nitriles.
The
X-ray
crystal
structure
Cu(OAc)2-TBAA
complex
also
revealed.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(32), С. 6565 - 6571
Опубликована: Янв. 1, 2023
Chemical
fixation
of
CO2
has
received
much
attention.
In
particular,
catalytic
C-C
bond
formation
with
giving
carboxylic
acids
is
great
significance.
Among
the
methods,
multiple
carboxylation
one
challenging
subjects.
Here
we
investigated
Cu-catalyzed
a
variety
boronic
acid
pinacol
esters
(C(sp2)-,
C(sp3)-,
and
C(sp)-B
compounds)
CO2,
which
efficiently
provided
corresponding
products,
including
aryl,
alkenyl,
alkyl,
alkynyl
acids.
This
was
also
applicable
to
di-
tri-carboxylic
under
robust
reaction
conditions
(totally
29
examples).
Synthesis,
Год журнала:
2024,
Номер
56(12), С. 1932 - 1940
Опубликована: Янв. 9, 2024
Abstract
A
simple
and
efficient
method
for
the
synthesis
of
1,4-dihydropyridines
from
amines,
N,N-dimethyl
enaminone
N,N-dimethylaminoethanol
in
a
four-component
[2+1+2+1]
annulation
catalyzed
by
FeCl3
has
been
established,
where
was
applied
as
methine
source.
The
procedure
executed
smoothly,
resulting
wide
range
with
moderate
to
good
yields.
Additionally,
these
fluorophores
exhibited
photophysical
characteristics.
