Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 21, 2022
A
transition-metal-free
method
for
the
construction
of
3-substituted
or
3,4-disubstituted
quinolines
from
readily
available
N,N-dimethyl
enaminones
and
o-aminobenzyl
alcohols
is
reported.
The
direct
oxidative
cyclocondensation
reaction
tolerates
broad
functional
groups,
allowing
efficient
synthesis
various
in
moderate
to
excellent
yields.
involves
a
C
(sp3)-O
bond
cleavage
C=N
bind
C=C
formation
during
cyclization
process,
mechanism
was
proposed.
Journal of Heterocyclic Chemistry,
Год журнала:
2021,
Номер
59(6), С. 969 - 996
Опубликована: Дек. 24, 2021
Abstract
Since
the
growing
importance
of
phenazine
derivatives,
efficient
synthetic
strategies
for
preparation
derivatives
have
attracted
great
attention
from
organic
methodology.
Herein,
we
comprehensively
review
and
summarize
a
series
sustainable
facile
derivatives.
Moreover,
further
discuss
approach
superiority
each
strategy.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(26), С. 5475 - 5480
Опубликована: Янв. 1, 2023
An
Fe-mediated
four-component
reaction
of
enaminones,
anhydrides
and
tetrahydrofuran
through
a
cascade
[1
+
2
3]-cyclization/esterification
process
is
presented.
This
protocol
provides
new
effective
method
to
construct
4-alkylated
1,4-dihydropyridines
with
an
ester
fragment.
Cyclic
ether
employed
as
the
C4
source
for
first
time.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(8), С. 5266 - 5276
Опубликована: Апрель 9, 2024
A
transition
metal-free
concise
and
efficient
protocol
for
the
synthesis
of
thiocyanated
aminomaleimides
benzo[e][1,4]thiazepine
derivatives
has
been
developed.
The
method
involves
an
initial
α-C–H
thiocyanation
with
KSCN
TEMPO-mediated
tandem
S–CN
bond
cleavage/intramolecular
cyclization
substitution
processes,
which
enables
formation
seven-membered
S/N-heterocycles.
This
synthetic
strategy
provides
a
reliable
biologically
interesting
by
using
as
sulfur
sources
well
expands
application
enaminones
reactions
in
heterocycles
synthesis.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Сен. 21, 2022
A
transition-metal-free
method
for
the
construction
of
3-substituted
or
3,4-disubstituted
quinolines
from
readily
available
N,N-dimethyl
enaminones
and
o-aminobenzyl
alcohols
is
reported.
The
direct
oxidative
cyclocondensation
reaction
tolerates
broad
functional
groups,
allowing
efficient
synthesis
various
in
moderate
to
excellent
yields.
involves
a
C
(sp3)-O
bond
cleavage
C=N
bind
C=C
formation
during
cyclization
process,
mechanism
was
proposed.
