Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(8), С. 1179 - 1184
Опубликована: Апрель 1, 2023
Abstract
Under
heating
conditions,
an
iron(II)‐catalyzed
cascade
cyanoalkylsulfonylation/cyclization
reaction
is
developed
to
produce
cyanoalkylsulfonylated
pyrrolidones
bearing
with
a
free
CN
moiety.
This
alkyl
radical
disconnection
and
annulation
protocol
enjoys
chemo‐
regioselectivity
the
tolerance
toward
range
of
functional
groups.
The
reactive
cyanoalkyl
radical,
which
was
originated
from
ring‐opening
cyclic
imine
found
be
capable
capturing
in‐situ
generated
“SO
2
”
species
DABSO,
thus
leading
production
sulfonyl
subsequent
alkene
sequences.
magnified
image
Organic Letters,
Год журнала:
2024,
Номер
26(9), С. 1834 - 1839
Опубликована: Фев. 22, 2024
Efficient
access
to
multiple
functionalized
allenes
via
a
three
component
1,4-alkylcyanation
of
enynes
with
cyclic
alcohol
derivatives
in
the
presence
trimethylsilyl
cyanide
(TMSCN)
under
copper/photoredox
dual
catalysis
has
been
developed.
Both
easily
transformable
aldehyde
and
cyano
groups
were
introduced
tetra-substituted
through
light-induced
C–C
bond
cleavage
butanol
pentanol
derivatives.
The
reactions
proceeded
smoothly
mild
conditions
broad
functional
tolerance.
Molecules,
Год журнала:
2022,
Номер
27(19), С. 6583 - 6583
Опубликована: Окт. 4, 2022
The
significant
scaffold
offered
by
atropisomeric
amides
with
a
C–N
chiral
axis
has
been
extensively
utilized
for
pharmaceuticals,
agricultural
science,
and
organic
syntheses.
As
result,
the
field
of
atropisomer
synthesis
attracted
considerable
interest
within
chemistry
communities.
To
date,
range
catalytic
atroposelective
approaches
reported
efficient
construction
these
challenging
scaffolds.
However,
greatly
concise
highly
useful
methodologies
compounds,
focusing
on
transition-metal,
amine,
phosphoric
acid
catalysis
reactions,
etc.,
are
still
desirable.
Hence,
it
is
indispensable
to
succinctly
systematically
present
all
such
reports
means
disclosing
mechanistic
analysis
application,
as
well
challenges
issues
associated
establishment
atropisomers.
In
this
review,
we
summarize
development
asymmetric
synthetic
strategies
access
non-biaryl
atropisomers
rotating
around
axis,
including
reaction
methods,
mechanism,
late-stage
transformations,
applications.
Organic Letters,
Год журнала:
2023,
Номер
25(31), С. 5916 - 5921
Опубликована: Июль 27, 2023
A
copper-catalyzed
trifluoromethylthio-arylsulfonylation
between
1,3-enynes,
AgSCF3,
aryldiazonium
tetrafluoroborates,
and
SO2
(from
SOgen)
is
presented,
which
could
introduce
sulfone,
SCF3,
allene
moieties
into
one
molecule
simultaneously.
This
strategy
features
mild
reaction
conditions,
good
substrate
compatibility,
excellent
regioselectivity.
The
products
obtained
have
the
potential
for
further
conversion
other
valuable
compounds.
Initial
investigations
mechanism
suggest
that
it
may
proceed
via
a
radical
pathway.
Notably,
SOgen
was
proven
as
uniquely
effective
surrogate
in
this
transformation.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(8), С. 1179 - 1184
Опубликована: Апрель 1, 2023
Abstract
Under
heating
conditions,
an
iron(II)‐catalyzed
cascade
cyanoalkylsulfonylation/cyclization
reaction
is
developed
to
produce
cyanoalkylsulfonylated
pyrrolidones
bearing
with
a
free
CN
moiety.
This
alkyl
radical
disconnection
and
annulation
protocol
enjoys
chemo‐
regioselectivity
the
tolerance
toward
range
of
functional
groups.
The
reactive
cyanoalkyl
radical,
which
was
originated
from
ring‐opening
cyclic
imine
found
be
capable
capturing
in‐situ
generated
“SO
2
”
species
DABSO,
thus
leading
production
sulfonyl
subsequent
alkene
sequences.
magnified
image
