Recent progress on Catellani reaction

Tetrahedron, Год журнала: 2023, Номер 134, С. 133307 - 133307

Опубликована: Фев. 10, 2023

Язык: Английский

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Copper-Catalyzed Annulation of O-Acyl Oximes with Cyclic 1,3-Diones for the Synthesis of 7,8-Dihydroindolizin-5(6H)-ones and Cyclohexanone-Fused Furans

Organic Letters, Год журнала: 2023, Номер 25(5), С. 838 - 842

Опубликована: Янв. 27, 2023

A copper-catalyzed annulation of O-acyl oximes with cyclic 1,3-diones has been developed for the concise synthesis 7,8-dihydroindolizin-5(6H)-ones and cyclohexanone-fused furans through substituent-controlled selective radical coupling process. 2-Alkyl undergo C-C coupling, while 2-unsubstituted C-O coupling.

Язык: Английский

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The Palladium/Norbornene‐Catalyzed Annulation Chemistry: Rapid Access to Diverse Ring Structures

Опубликована: Фев. 28, 2025

Язык: Английский

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Asymmetric Palladium/Norbornene Cooperative Catalysis

Опубликована: Фев. 28, 2025

Язык: Английский

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Recent Developments of Palladium- and Rhodium-Catalyzed β-Carbon Elimination Strategies

Synthesis, Год журнала: 2023, Номер 55(15), С. 2285 - 2303

Опубликована: Янв. 22, 2023

Abstract The activation of C–C bonds via transition metal catalysis has become an increasingly popular strategy in organic synthesis. An emerging method to cleave is facilitate a β-carbon elimination using rhodium or palladium catalysis. This elementary step typically relies on thermodynamic driving force, such as the relief ring strain steric strain. More recently, use neopentyl species chelation assistance enabled this difficult transformation. review will cover recent synthetic applications eliminations under and 1 Introduction 2 Chelation-Assisted β-Carbon Elimination Reactions 3 from Neopentyl–Pd Species 4 Pd-Catalyzed Catellani 5 Cyclopropanes 6 Conclusion

Язык: Английский

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Copper-Catalyzed [3 + 2] Annulation of O-Acyl Oximes with 4-Sulfonamidophenols for the Synthesis of 5-Sulfonamidoindoles and 2-Amido-5-sulfonamidobenzofuran-3(2H)-ones

Organic Letters, Год журнала: 2024, Номер 26(20), С. 4229 - 4234

Опубликована: Май 13, 2024

A copper-catalyzed [3 + 2] annulation of

Язык: Английский

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Direct Synthesis of C4-Acyl Indoles via C–H Acylation

Organic Letters, Год журнала: 2024, Номер 26(23), С. 4998 - 5003

Опубликована: Июнь 5, 2024

The direct synthesis of C4-acyl indoles deprived C2 and C3 substituents has proven to be challenging, with scarce efficient synthetic routes being reported. Herein, we disclose a highly site-selective palladium-catalyzed C-H acylation for the construction via Catellani-Lautens cyclization strategy. In addition, systematically studied

Язык: Английский

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The Reaction of Aryl Thiols or Thioureas with o‐Diiodoarenes/NaH to Access o‐Iodoaryl Thioethers

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(7), С. 1538 - 1544

Опубликована: Фев. 8, 2024

Abstract Herein we report a method for the synthesis of thioethers by forging C(aryl)‐S bond via an aryne mechanism. The active species can be generated from o ‐diiodoarenes and NaH in THF at room temperature, then lead to arylations wide range aryl thiols thioureas. Different transition metal‐catalyzed cross‐coupling reactions, no disubstituted byproduct is formed our protocol. ‐iodoaryl thioether products are intermediates that could transformed into pharmaceutically interesting molecules.

Язык: Английский

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A Cascade Synthesis of Indoles

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10293 - 10298

Опубликована: Июль 4, 2024

We report herein an expedient method for the regioselective synthesis of indoles from

Язык: Английский

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Modular Synthesis of ortho‐Thiolated Aryl Esters Enabled with Thiocarbonate through Catellani Strategy

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(6)

Опубликована: Янв. 3, 2023

Abstract Herein, we report a palladium/norbornene/copper co‐catalyzed single‐step approach that merges selective ortho C−H bond esterification with ipso thiolation for construction of synthetically versatile 2‐arylthio aryl esters under exceptionally mild conditions. Importantly, this process proceeded in highly efficient manner, allowing alkoxycarbonyl and thio groups to be installed into one iodides simultaneously by harnessing thiocarbonate as bifunctional reagent. The method has been demonstrated accommodate good functionalities features broad substrate scope.

Язык: Английский

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