Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(6)
Опубликована: Апрель 26, 2023
Abstract
A
NaH‐promoted
domino
reaction
between
azadiene
bearing
an
indene
moiety
with
Nazarov
reagent
was
developed.
variety
of
spiro[4.5]decane
derivatives
were
obtained
via
[4+2]
cycloaddition
good
yields
and
high
diastereoselectivity.
The
strategy
benefited
from
mild
conditions
very
broad
substrate
scope.
Furthermore,
a
gram‐scale
experiment
transformation
the
product
carried
out.
Lastly,
density
functional
theory
(DFT)
calculations
have
been
performed
to
verify
proposed
mechanism
analyze
observed
Organic Letters,
Год журнала:
2023,
Номер
25(38), С. 7057 - 7061
Опубликована: Сен. 13, 2023
A
TFA-catalyzed
dehydrofluorinative
cyclization
of
2,2-difluoro-3-hydroxy-1,4-diketones
has
been
developed
in
the
presence
amines
under
mild
conditions
which
difluorinated
substrates
are
readily
prepared
according
to
our
reported
literature.
This
protocol
provides
a
rapid
construction
fluoro
3(2H)-furanones
good
excellent
yields
with
functional
group
tolerance.
Easy
scale-up
synthesis
also
shows
practical
advantage.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(6)
Опубликована: Апрель 26, 2023
Abstract
A
NaH‐promoted
domino
reaction
between
azadiene
bearing
an
indene
moiety
with
Nazarov
reagent
was
developed.
variety
of
spiro[4.5]decane
derivatives
were
obtained
via
[4+2]
cycloaddition
good
yields
and
high
diastereoselectivity.
The
strategy
benefited
from
mild
conditions
very
broad
substrate
scope.
Furthermore,
a
gram‐scale
experiment
transformation
the
product
carried
out.
Lastly,
density
functional
theory
(DFT)
calculations
have
been
performed
to
verify
proposed
mechanism
analyze
observed
