TfOH-catalyzed direct Michael addition and cascade cyclization reactions of unactivated ketones: A divergent route to functionalized benzofurans and benzofuro[3,2-b]pyridines

Tetrahedron, Journal Year: 2023, Volume and Issue: 137, P. 133394 - 133394

Published: April 1, 2023

Language: Английский

Synthesis of Fluoro 3(2H)-Furanones via a TFA-Catalyzed Dehydrofluorinative Cyclization of 2,2-Difluoro-3-hydroxy-1,4-diketones

Organic Letters, Journal Year: 2023, Volume and Issue: 25(38), P. 7057 - 7061

Published: Sept. 13, 2023

A TFA-catalyzed dehydrofluorinative cyclization of 2,2-difluoro-3-hydroxy-1,4-diketones has been developed in the presence amines under mild conditions which difluorinated substrates are readily prepared according to our reported literature. This protocol provides a rapid construction fluoro 3(2H)-furanones good excellent yields with functional group tolerance. Easy scale-up synthesis also shows practical advantage.

Language: Английский

Construction of Spiro[4.5]decanes via Annulations of Azadienes with Nazarov Reagent and DFT Studies

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(6)

Published: April 26, 2023

Abstract A NaH‐promoted domino reaction between azadiene bearing an indene moiety with Nazarov reagent was developed. variety of spiro[4.5]decane derivatives were obtained via [4+2] cycloaddition good yields and high diastereoselectivity. The strategy benefited from mild conditions very broad substrate scope. Furthermore, a gram‐scale experiment transformation the product carried out. Lastly, density functional theory (DFT) calculations have been performed to verify proposed mechanism analyze observed

Language: Английский