A new type of heterogeneous catalysis strategy for organic reactions: Ugi-3CR catalyzed by highly stable MOFs with exposed carboxyl groups

Organic Chemistry Frontiers, Год журнала: 2022, Номер 9(22), С. 6179 - 6186

Опубликована: Янв. 1, 2022

A mild and highly efficient Ugi-3CR using a novel Cu-COOH@MOF-6 as the catalyst has been developed, which provides facile access to α-amino amides. The recycling test XRD images showed that catalytic system good stability recyclability.

Язык: Английский

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Three-Component Domino Reaction of Thioamide, Isonitriles, and Water: Selective Synthesis of 1,2,4-Thiadiazolidin-3-ones and (E)-N-(1,2-Diamino-2-thioxoethylidene)benzamides

The Journal of Organic Chemistry, Год журнала: 2023, Номер 89(12), С. 8315 - 8325

Опубликована: Янв. 24, 2023

The three-component domino reaction of thioamides, benzyl isocyanide, and water in the presence a catalytic amount both Pd(dppf)Cl2 Cu(OAc)2 afforded novel 1,2,4-thiadiazolidin-3-one cyclic compounds, whereas same with tertiary alkylisonitriles rare earth metal salt [La(OTf)3] resulted (E)-N-(1,2-diamino-2-thioxoethylidene)benzamide open-chain products. This divergent enabled one-pot construction five (N–S, C–S, C–O, two C–N) or four (C–S, C–N, C–C) new chemical bonds. Mechanism studies indicate that oxygen atom product was derived from H2O.

Язык: Английский

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Construction of Tetrazole Derivatives via Sequential Ugi‐N₃/Pd‐Catalyzed Isocyanide Insertion Reactions

ChemistrySelect, Год журнала: 2023, Номер 8(5)

Опубликована: Фев. 1, 2023

Abstract Herein, a straightforward method for the construction of tetrazole derivatives has been achieved through Pd‐catalyzed isocyanide insertion reactions, which is good extension response multi‐molecule isocyanides. The Ugi‐N 3 reaction was introduced to transformation enrich diversity skeleton structures. commercially available starting materials and moderate yields make this valuable tool generating N‐containing heterocyclic compounds.

Язык: Английский

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Recent Progress in Pd-Catalyzed Tandem Processes

Catalysts, Год журнала: 2023, Номер 13(8), С. 1213 - 1213

Опубликована: Авг. 15, 2023

In recent years, Pd-containing catalytic systems for tandem processes have gained special attention due to their enhanced properties and possibility of performing several reactions without the necessity separating intermediates. this review, progress in Pd-catalyzed is considered. Three types are described: homogeneous catalysts (including immobilized Pd complexes); heterogeneous supported on oxides, MOFs, COFs, etc., with particular supports containing acid/base sites; metal-enzyme chemoenzymatic applied fine organic synthesis biotechnology. For reactions, different were considered, i.e., cross-coupling, cyclization, carbonylation, isomerization, alkylation, arylation, etc.

Язык: Английский

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Palladium-Catalyzed Tandem C(sp³)-H Insertion Cyclization of 2-(2-Vinylarene)acetonitriles with Isocyanides to Access Naphthalen-2-amines

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(17), С. 12409 - 12420

Опубликована: Авг. 14, 2023

A Pd-catalyzed cyclization reaction of 2-(2-vinylarene)acetonitriles and isocyanides has been documented. Various naphthalen-2-amines were obtained in moderate to good yields under mild conditions. The vitro cytotoxicity all products was evaluated by MTT assay against seven human cancer cell lines. results indicated that compounds 3ea, 3ma, 3ob exhibited effective anticancer activities the tested cells.

Язык: Английский

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Fabricating Effective and Recyclable Cadmium‐based Coordination Polymer for Selective Synthesis of 1,5‐Benzodiazepines

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(12)

Опубликована: Окт. 9, 2023

Abstract Metal coordination polymers are widely applied in the synthesis of heterocyclic compounds due to advantages highly dispersed metal active sites, low cost and strong designability. Herein, employing 9‐benzyl‐3,6‐di( 1H ‐pyrazol‐1‐yl)‐ 9H ‐carbazole (BPC) as a ligand, cadmium‐coordinated polymer compound (Cd‐BPC) was facilely prepared by solvothermal method characterized energy dispersive spectrometer (EDS), flourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscope (SEM), transmission microscopy (TEM) X‐ray photoelectron spectrometry (XPS). Employing Cd‐BPC catalyst, 1,5‐benzodiazepine derivatives were produced with relatively high yields through reaction o ‐phenylenediamine ketones, alcohols. Additionally, could be reused for at least 5 times without significant decrease.

Язык: Английский

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Five-membered ring systems: pyrroles and benzo analogs

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 199 - 250

Опубликована: Янв. 1, 2023

Язык: Английский

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Solvent-involved synthesis of pyrrolidin-5-one-2-carboxamides via a sequential Ugi/olefination reaction

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(10), С. 2780 - 2785

Опубликована: Янв. 1, 2024

An unprecedented multi-component reaction with solvent participation and a novel conversion of sulfur ylides was developed via Ugi/olefination to construct pyrrolidin-5-one-2-carboxamides.

Язык: Английский

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Design and synthesis of tetrazole-linked quinazoline derivatives and their bioactivities against Microcystis aeruginosa FACHB905

Tetrahedron Letters, Год журнала: 2024, Номер 140, С. 155046 - 155046

Опубликована: Апрель 1, 2024

Язык: Английский

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