Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 23, 2023
Abstract
Photocatalytic
C
−
coupling
reaction
plays
an
important
role
in
the
synthesis
of
organics
that
are
widely
used
as
fine
chemicals,
medicine
and
pesticides.
However,
development
high-performance,
low-cost
photocatalysts
to
drive
under
mild
conditions
remains
a
severe
challenge.
Herein,
we
present
green
photocatalytic
method
for
selective
bibenzyl
over
ultrathin
TiO
2
(B)
nanosheet
photocatalyst
with
single-atom
Cu
anchored
rich
oxygen
vacancy
(V
O
),
which
were
generated
in-situ
system.
The
requires
no
tedious
pre-functionalization
steps,
allows
use
cheap
copper
compounds
starting
materials.
experimental
results
show
introduction
sites
on
can
improve
charge
transfer
separation
efficiency,
presence
surface
V
not
only
improves
light
absorption
capacity
but
also
favors
adsorption
activation
reactant
benzyl
bromide.
More
importantly,
synergy
endows
high
efficiency
bibenzyl.
This
work
provides
novel
insight
into
through
collaborative
strategy
species
photocatalysts.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(16), С. 11762 - 11766
Опубликована: Авг. 9, 2023
A
metal-free
addition
of
unactivated
alkyl
bromides
to
quinoxalin-2(1H)-ones
is
described.
This
method
enables
the
construction
valuable
3,3-disubstituted
dihydroquinoxalin-2(1H)-ones
bearing
quaternary
carbon
centers
under
mild,
visible-light
photoredox
catalysis.
High
functional
group
tolerance
observed
in
both
quinoxalinone
and
bromide
partners.
The
ability
scale
up
this
was
demonstrated
photo-flow
conditions
enable
gram-scale
synthesis.
Synthesis,
Год журнала:
2023,
Номер
55(13), С. 2091 - 2098
Опубликована: Фев. 14, 2023
Abstract
A
novel
and
efficient
visible-light-induced
method
is
developed
for
the
one-pot
synthesis
of
functionalized
2-aminothiazoles
from
easily
accessible
active
methylene
ketone
derivatives
different
thioureas
at
room
temperature.
The
mild
reaction
conditions,
green
chemistry,
straightforward
work-up,
high
yields
products
make
this
procedure
useful
construction
2-aminothiazole
derivatives.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(68)
Опубликована: Авг. 28, 2024
The
visible
light-induced
decarboxylative
cascade
reaction
of
fluoroalkyl
carboxylic
acids
has
been
achieved
for
the
efficient
synthesis
fluorinated
compounds.
However,
most
transformations
rely
on
noble
iridium
metal
complex.
Herein,
a
metal-free
realized.
This
protocol
features
simple
operation,
transition
free,
and
good
functional
group
tolerance.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
An
efficient
visible-light-induced
radical
carbon
oximation
of
styrenes
with
1-nitrosopyrrolidine
and
organic
halides
is
developed.
The
reaction
proceeds
smoothly
in
the
absence
a
transition
metal
photocatalyst
under
mild
conditions,
producing
wide
range
functionalized
oximes
moderate
to
good
yields.
Mechanistic
studies
reveal
that
involves
generation
nucleophilic
α-amino
alkyl
radicals
subsequent
halogen
atom
transfer
(XAT)
halides.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(13), С. 8010 - 8023
Опубликована: Июнь 1, 2023
Quinoxalinones
are
a
privileged
class
of
compounds,
and
their
structural
framework
is
found
in
many
bioactive
natural
pharmaceuticals.
Quinoxalinone
promising
scaffold
for
different
types
functionalization,
the
slight
modification
quinoxalinone
skeleton
known
to
offer
wide
range
compounds
drug
discovery.
Owing
importance
scaffold,
we
have
developed
base-mediated
protocol
C3-alkylation
followed
by
tandem
cyclization
access
novel
strenuous
fused
dihalo-aziridino-quinoxalinone
heterocycles
via
construction
C–C
C–N
bonds.
The
proved
be
simple
practical
desired
excellent
yields
(up
98%
yield).
As
an
application,
highly
functionalized
molecule
has
been
further
utilized
mono-dehalogenation
under
visible
light
irradiation
selective
amide
reduction.
Moreover,
also
demonstrated
on
gram
scale.
ACS Omega,
Год журнала:
2023,
Номер
9(1), С. 651 - 657
Опубликована: Дек. 16, 2023
We
report
herein
an
efficient
visible-light-promoted
approach
for
the
regioselective
decarboxylative
C–H
acylation
of
N-methyl-3-phenylquinoxalin-2(1H)-ones
using
α-oxo-2-phenylacetic
acids
via
dual
palladium–photoredox
catalysis.
The
reactions
were
carried
out
at
room
temperature
in
presence
24
W
blue
LEDs.
established
protocol
tolerated
a
wide
range
functional
groups
and
enabled
synthesis
several
acylated
good
to
excellent
yields.
proposed
mechanism
this
transformation
was
supported
by
control
experiments.
