Tetrahedron Letters, Год журнала: 2024, Номер unknown, С. 155319 - 155319
Опубликована: Окт. 1, 2024
Язык: Английский
Tetrahedron Letters, Год журнала: 2024, Номер unknown, С. 155319 - 155319
Опубликована: Окт. 1, 2024
Язык: Английский
Organic Letters, Год журнала: 2023, Номер 25(32), С. 6072 - 6076
Опубликована: Авг. 8, 2023
A novel and efficient strategy for the synthesis of a series structurally interesting benzazepine derivatives via an N-heterocyclic carbene-catalyzed regioselective intramolecular radical cyclization has been developed. This protocol features good regioselectivity, functional-group compatibility, wide substrate scope, providing transition-metal- oxidant-free pathway to access seven-membered rings under mild reaction conditions. Additionally, further transformation benzazepines large-scale experiment were also conducted.
Язык: Английский
Процитировано
12Organic Letters, Год журнала: 2022, Номер 24(50), С. 9243 - 9247
Опубликована: Дек. 14, 2022
A number of γ-cyanoalkyl radicals were generated by sustainable N-heterocyclic carbene catalysis in tin-, transition-meal-, and light-free conditions, followed insertion into biaryl isonitriles, thus leading to the rapid assembly a variety diversely functionalized 6-cyanoalkyl phenanthridines. preliminary mechanism study revealed that single-electron transfer radical process was possibly involved.
Язык: Английский
Процитировано
17Organic Letters, Год журнала: 2023, Номер 25(51), С. 9186 - 9190
Опубликована: Дек. 15, 2023
The photoredox/PPh3-mediated cyclization of 2-isocyanobiaryls has been developed. A substantial range functional-group-rich phenanthridine derivatives were synthesized at room temperature in a highly selective and atom-economic manner. Mechanistic studies suggested that the process is probably mediated both by Ph3P radical cation with key 1,2-hydride transfer hydrogen atom generated through O–H bond homolytic cleavage Ph3P–OH intermediate.
Язык: Английский
Процитировано
11ChemistryOpen, Год журнала: 2024, Номер unknown
Опубликована: Июль 11, 2024
Abstract This review introduces the synthetic organic chemical value of α‐bromocarbonyl compounds with tertiary carbons. compound a carbon has been used primarily only as radical initiator in atom transfer polymerization (ATRP) reactions. However, recent development photo‐radical reactions (around 2010), research on use alkyl precursors became popular 2012). As more examples were reported, studied not radicals but also for their applications organometallic and ionic That is, act nucleophiles well electrophiles. The carbonyl group is attractive because it allows skeleton to be converted after reaction, being applied total synthesis. In our survey until 2022, can perform full range necessary synthesis, including multi‐component reactions, cross‐coupling, substitution, cyclization, rearrangement, stereospecific asymmetric α‐Bromocarbonyl have created new trend alkylation, which then had limited reaction patterns focuses how chemistry.
Язык: Английский
Процитировано
4Organic Letters, Год журнала: 2024, Номер 26(38), С. 8149 - 8153
Опубликована: Сен. 16, 2024
Indole and quinoline structures are present in numerous biologically active molecules, making the synthesis of their glycosylation products a subject extensive research interest drug development. Here, we report photoredox strategy for
Язык: Английский
Процитировано
3Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
A photochemical radical cascade cyclization reaction of isocyanides with α-carbonyl bromides under mild conditions is disclosed for accessing 1,4-dibenzodiazepines, demonstrating good tolerance towards various functional groups.
Язык: Английский
Процитировано
0Tetrahedron Chem, Год журнала: 2025, Номер unknown, С. 100124 - 100124
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 23, 2025
Quinolines, a significant part of nitrogen-containing heterocycles, are widely found in functional compounds. Herin, photochemical radical cyclization reaction o-vinylaryl isocyanides and aryldiazonium tetrafluoroborates, has been reported to build 2,4-diaryl quinolines. Readily accessible aryl diazonium salts were utilized as precursors at room temperature. This approach allowed good group tolerance substrate applicability.
Язык: Английский
Процитировано
0Synthetic Communications, Год журнала: 2025, Номер unknown, С. 1 - 9
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
0Green Synthesis and Catalysis, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0