Thermocatalytic Conversion of CO₂ to Valuable Products Activated by Noble‐Metal‐Free Metal‐Organic Frameworks

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(34)

Опубликована: Май 12, 2023

Thermocatalysis of CO2 into high valuable products is an efficient and green method for mitigating global warming other environmental problems, which Noble-metal-free metal-organic frameworks (MOFs) are one the most promising heterogeneous catalysts thermocatalysis, many excellent researches have been published. Hence, this review focuses on obtained from various conversion reactions catalyzed by noble-metal-free MOFs, such as cyclic carbonates, oxazolidinones, carboxylic acids, N-phenylformamide, methanol, ethanol, methane. We classified these published references according to types products, analyzed methods improving catalytic efficiency MOFs in reaction. The advantages using MOF were also discussed along text. This concludes with future perspectives challenges be addressed potential research directions. believe that will helpful readers attract more scientists join topic conversion.

Язык: Английский

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Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles

ChemistrySelect, Год журнала: 2023, Номер 8(47)

Опубликована: Дек. 13, 2023

Abstract Nitrogen‐containing heterocycles such as imidazoles, thiazoles, and oxazoles play a significant role in the fields of biological pharmaceutical chemistry. These compounds were widely used for agrochemical, pesticide, medicinal, industrial applications. Due to wide spectrum structural diversity well activity N ‐heterocycles, plethora reports on their synthesis have appeared last few decades. However, developments various bond‐forming strategies C−C, C−N, C−O, C−S, N−N, C−H activation, been powerful synthetic tool derive copious ‐heterocycles. The most prominent fascinating imidazole, thiazole, oxazoles, benzimidazole moieties by C−C C−N coupling reactions, multi‐component cycloaddition etc. are discussed this study. studies demonstrated enormous potential methods accelerating modern chemical establishing molecular beauty through bonding. aspects methodologies, like optimized conditions, substrate scope, mechanistic investigations, detail.

Язык: Английский

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Visible Light-Induced Radical Cascade Difluoromethylation/Cyclization of Unactivated Alkenes: Access to CF₂H-Substituted Polycyclic Imidazoles

ACS Omega, Год журнала: 2024, Номер 9(26), С. 28129 - 28143

Опубликована: Июнь 19, 2024

An efficient and mild protocol for the visible light-induced radical cascade difluoromethylation/cyclization of imidazoles with unactivated alkenes using easily accessible bench-stable difluoromethyltriphenylphosphonium bromide as precursor -CF

Язык: Английский

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Rh(III)‐Catalyzed C‐H Cyclization of 2‐Arylbenzimidazoles with CF3‐Imidoyl Sulfoxonium Ylides and Further Sc(III)‐Catalyzed Deaminative Hydroxylation

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 16, 2024

Abstract An efficient Rh(III)‐catalyzed C−H bond activation/cyclization of 2‐arylbenzimidazoles with CF 3 ‐imidoyl sulfoxonium ylides has been achieved, yielding diverse − and amino‐disubstituted 5,6‐dihydrobenzoimidazo[2,1‐ a ]isoquinolines, which could undergo deaminative hydroxylation to access hydroxy‐disubstituted ]isoquinolines catalyzed by Sc(OTf) . This developed strategy features easily available starting materials, broad substrate scope, good scalability high efficiency. Moreover, the antitumor activities selected products against some human cancer cell lines were also investigated, results indicated that several show antiproliferative activities.

Язык: Английский

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Investigating the inhibition of benzimidazole derivatives on SARS-CoV-2 M ^pro by enzyme activity inhibition, spectroscopy, and molecular docking

Journal of Biomolecular Structure and Dynamics, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Фев. 19, 2025

The inhibition of twenty-five 1,2-fused/disubstituted benzimidazoles on the SARS-CoV-2 Mpro were investigated in this work. It was found that four compounds (1i, 1k, 1l, and 1m) showed obvious inhibitory effect Mpro. 1k (IC50 46.86 μM) best. UV-vis, fluorescence, CD molecular docking methods used to reveal mechanisms interaction between these Results indicated static quenching main type quenching. 1i, 1m may alter conformation microenvironment dominant forces 1i (or 1l) hydrogen bonds or van der Waals forces. electrostatic hydrophobic forces, which consistent with results docking. influence structure binding investigated. Chlorine atom groups favorable for derivative inhibitors This work confirmed changes micro-environment by provided clues design potential inhibitors.

Язык: Английский

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Iodine-Mediated δ-Amination of sp³ C–H Bonds

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(5), С. 3481 - 3490

Опубликована: Фев. 21, 2024

We present a direct δ-amination reaction of sp

Язык: Английский

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A One-Pot Cascade Strategy toward Organocatalytic Enantioselective Construction of Fused Benzimidazoles

Organic Letters, Год журнала: 2024, Номер 26(21), С. 4502 - 4507

Опубликована: Май 20, 2024

Herein, we describe an asymmetric assembly of ortho-aromatic diamines and formyl tethered Michael acceptors forming chiral fused benzimidazoles. A cinchona-alkaloid-derived bifunctional squaramide catalyst enables the methodology through on-site dihydrobenzimidazole formation followed by aza-Michael addition/oxidation cascade. This protocol stands out for its excellent catalytic efficiency over background reaction mild conditions, making it more practical. Various acceptors, including enones, ester, thioester, were successful substrates in this study. Additionally, has demonstrated scalability successfully showcased postsynthetic transformations.

Язык: Английский

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Iodine-Mediated α-C–H Amination of Carbonyl Compounds via Nitrogen-Directed Oxidative Umpolung

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(13), С. 8751 - 8760

Опубликована: Июнь 12, 2023

A new synthetic strategy for direct C(sp3)–H amination of carbonyl compounds at their α-carbon has been established employing molecular iodine and nitrogen-directed oxidative umpolung. In this transformation, acts not only as an iodinating reagent but also a Lewis acid catalyst, both the nitrogen-containing moiety group in substrate play important roles. This approach is applicable to broad variety substrates, including esters, ketones, amides. Its features include no requirement transition metals, mild reaction conditions, short times, gram-scale synthesis.

Язык: Английский

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I₂‐Mediated Oxidation of Amines in Water toward Imines and Amides

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(6)

Опубликована: Май 2, 2023

Abstract A sustainable oxidation reaction of amines in water is established for the synthesis imines and amides employing environmentally benign molecular iodine as sole oxidant. The features present also include no use transition metals, operational simplicity gram‐scale synthesis. It provides a facile access to imine amide derivatives including bioactive molecules from readily accessible amine precursors.

Язык: Английский

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Manganese‐catalyzed Efficient Synthesis of N‐heterocycles and Aminoketones Using Glycerol as a C3 Synthon

Chemistry - A European Journal, Год журнала: 2024, Номер 30(14)

Опубликована: Янв. 18, 2024

Abstract Glycerol is one of the important biomass‐derived feedstocks and high‐value utilizations glycerol have attracted much attentions in recent years. Herein, we report a manganese catalyzed dehydrogenative coupling with amines for synthesis substituted 2‐methylquinoxalines, 2‐ethylbenzimidazoles, α ‐aminoketones without any external oxidant. In these reactions, NHC‐based pincer complex featuring pyridine backbone displayed high catalytic activity selectivity, which hydrogen water were produced as only by‐products using C3 synthon.

Язык: Английский

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