Natural Sesquiterpenoids, Diterpenoids, Sesterterpenoids, and Triterpenoids with Intriguing Structures from 2017 to 2022
Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(22), С. 3115 - 3132
Опубликована: Июнь 17, 2023
Comprehensive
Summary
This
review
covers
the
isolation,
structural
determination,
plausible
biosynthetic
pathways,
and
biological
activities
of
166
natural
terpenoids
including
57
sesquiterpenoids,
65
diterpenoids,
15
sesterterpenoids,
29
triterpenoids
from
January
2017
to
December
2022.
Язык: Английский
Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity
Bioorganic Chemistry,
Год журнала:
2024,
Номер
154, С. 107989 - 107989
Опубликована: Ноя. 22, 2024
Язык: Английский
Anti-inflammatory lanostane triterpenoids with rearranged spirobi[indene] scaffold and their biogenetically related analogues from Euphorbia maculata
Phytochemistry,
Год журнала:
2023,
Номер
211, С. 113682 - 113682
Опубликована: Апрель 19, 2023
Язык: Английский
Hot off the Press
Natural Product Reports,
Год журнала:
2023,
Номер
40(2), С. 223 - 227
Опубликована: Янв. 1, 2023
A
personal
selection
of
32
recent
papers
is
presented
covering
various
aspects
current
developments
in
bioorganic
chemistry
and
novel
natural
products,
such
as
euphylonoid
from
Euphorbia
hylonoma.
Язык: Английский
Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux
Journal of Asian Natural Products Research,
Год журнала:
2024,
Номер
26(8), С. 900 - 909
Опубликована: Май 16, 2024
Nine
jatrophane
diterpenoids
were
isolated
from
the
whole
plant
Euphorbia
helioscopia,
including
two
new
ones,
helioscopnins
A
(1)
and
B
(2).
Comprehensive
spectroscopic
data
analysis
ECD
calculations
elucidated
their
structures,
absolute
configurations.
All
compounds
evaluated
for
bioactivity
towards
autophagic
flux
by
flow
cytometry
using
HM
mCherry-GFP-LC3
cells.
Compounds
1,
3,
4,
5,
8,
9
significantly
increased
flux.
Язык: Английский
Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Comprehensive
Summary
Terpenoids
are
a
large
and
diverse
family
of
secondary
metabolites
that
have
gained
more
attention
from
chemists
pharmacologists
for
their
intriguing
skeletons
broad
biological
activities,
including
anti‐inflammatory,
antitumoral,
antimicrobial,
anti‐viral
effects.
Based
on
the
previous
reviews,
this
review
comprehensively
summarized
recent
advances
bioactive
terpenoids,
focusing
structural
features
promising
covering
literature
2020
to
2023.
In
review,
532
terpenoids
with
remarkable
chemical
architectures
properties
classified
into
sesquiterpenoids
(142),
diterpenoids
(129),
sesterterpenoids
(24),
triterpenoids
(52),
meroterpenoids
(185),
were
isolated
terrestrial
marine
resources.
This
would
provide
reference
researchers
rapidly
discover
interesting
further
study
as
drug
leads.
Язык: Английский
New halimane and clerodane diterpenoids from Croton cnidophyllus
Xun Wei,
Jia-Luo Huang,
Hua-Hua Gao
и другие.
Natural Products and Bioprospecting,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 6, 2023
Three
new
halimane
furanoditerpenoids
(1-3)
and
three
clerodane
(4-6),
along
with
seven
known
terpenoids
including
four
pimarane
diterpenoids
(7-10)
norisoprenoids
(11-13)
were
isolated
from
the
95%
EtOH
extracts
of
plants
Croton
cnidophyllus.
The
2D
structures
absolute
configuration
(1-6)
elucidated
by
analysis
their
HRMS
NMR
data
as
well
comparison
experimental
calculated
ECD
curves.
Bioassay
revealed
that
two
compounds
(8
9)
possessed
certain
inhibitory
effects
against
NO
production
stimulated
LPS,
IC50
values
19.00
±
1.76
21.61
1.11
μM,
respectively.
Язык: Английский
Discovery of Ingenane Diterpenoids from Euphorbia hylonoma as Antiadipogenic Agents
Journal of Natural Products,
Год журнала:
2023,
Номер
86(12), С. 2691 - 2702
Опубликована: Ноя. 17, 2023
Thirteen
new
Euphorbia
diterpenoids,
euphylonanes
A–M
(1–13),
and
eight
known
ones
were
isolated
from
the
whole
plants
of
hylonoma.
Compounds
1
2
are
two
rearranged
ingenanes
bearing
a
rare
6/6/7/3-fused
ring
system.
Compound
3
represents
first
example
9,10-epoxy
tigliane,
while
4–21
typical
varying
with
substituents.
Structures
elucidated
using
combination
spectroscopic,
computational,
chemical
methods.
Most
exerted
significant
antiadipogenic
effect
in
3T3-L1
adipocytes,
among
which
4
was
most
active
an
EC50
value
0.60
±
0.27
μM.
Mechanistic
study
revealed
that
inhibited
adipogenesis
lipogenesis
adipocytes
via
activation
AMPK
signaling
pathway.
Язык: Английский