Cyanation with isocyanides: recent advances and perspectives

Chemical Communications, Год журнала: 2024, Номер 60(12), С. 1546 - 1562

Опубликована: Янв. 1, 2024

This review focuses on the cyanation of isocyanides with recent advances and perspectives.

Язык: Английский

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Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles

ChemistrySelect, Год журнала: 2023, Номер 8(47)

Опубликована: Дек. 13, 2023

Abstract Nitrogen‐containing heterocycles such as imidazoles, thiazoles, and oxazoles play a significant role in the fields of biological pharmaceutical chemistry. These compounds were widely used for agrochemical, pesticide, medicinal, industrial applications. Due to wide spectrum structural diversity well activity N ‐heterocycles, plethora reports on their synthesis have appeared last few decades. However, developments various bond‐forming strategies C−C, C−N, C−O, C−S, N−N, C−H activation, been powerful synthetic tool derive copious ‐heterocycles. The most prominent fascinating imidazole, thiazole, oxazoles, benzimidazole moieties by C−C C−N coupling reactions, multi‐component cycloaddition etc. are discussed this study. studies demonstrated enormous potential methods accelerating modern chemical establishing molecular beauty through bonding. aspects methodologies, like optimized conditions, substrate scope, mechanistic investigations, detail.

Язык: Английский

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Pd-catalyzed imine-directed one-pot access to polysubstituted pyrrolesviatandem triple isocyanide insertion/aza-Nazarov cyclization reactions

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(13), С. 3252 - 3258

Опубликована: Янв. 1, 2023

A novel one-pot method for synthesizing polysubstituted pyrrole derivatives via three-component reactions of alkenyl bromides, amines, and isocyanides is reported by Pd catalysis, without additional ligands, with the orderly insertion three isocyanide molecules.

Язык: Английский

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C–H functionalization enabled by multiple isocyanides

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review outlines in detail strategies for state-of-the-art synthetic routes and demonstrates various interactions from the synergistic combination of C–H functionalization with multiple isocyanides to establish complicated reactions.

Язык: Английский

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One-Pot Regioselective Synthesis of Spiroimidazolidinones via a Sequential Ugi 4CR/Azide-Isocyanide Coupling/Cyclization/Rearrangement/Hydroxylation Reaction

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Herein a novel and robust methodology to spiroimidazolidinones has been developed under mild reaction. The reaction of (Z)-2-azido-3-phenylacrylic acids 1, aldehydes 2, amines 3, isocyanides 4, 6 produced regioselectively in 71–88% yields via sequential Ugi 4CR/Pd(0) catalyzed azide-isocyanide coupling/cyclization/rearrangement/hydroxylation Furthermore, the easily accessible starting materials, high bond-forming efficiency, broad substituent tolerance make this strategy useful synthetic medicinal chemistry.

Язык: Английский

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Hydrogen bond-promoted regio- and stereoselective synthesis of isoindoline derivatives through Pd-catalyzed isocyanide insertion reaction involving aziridines

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(6), С. 1775 - 1781

Опубликована: Янв. 1, 2024

We have successfully demonstrated an efficient and practical Pd-catalyzed reaction between aziridine isocyanide, leading to the synthesis of isoindoline derivatives in moderate good yields.

Язык: Английский

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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(18), С. 3684 - 3692

Опубликована: Янв. 1, 2024

Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O under oxidant-free conditions are outlined.

Язык: Английский

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Recent Developments in the Metal-Free Synthesis of Oxazoles

Tetrahedron, Год журнала: 2024, Номер 169, С. 134363 - 134363

Опубликована: Ноя. 9, 2024

Язык: Английский

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Accessing indole–isoindole derivatives via palladium-catalyzed [3+2] cyclization of isocyanides with alkynyl imines

Chemical Communications, Год журнала: 2023, Номер 59(70), С. 10540 - 10543

Опубликована: Янв. 1, 2023

An unprecedented route for the preparation of indole–isoindole derivatives was developed and proceeds via a palladium-catalyzed [3+2] cyclization isocyanides with alkynyl imines.

Язык: Английский

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Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles

Chinese Chemical Letters, Год журнала: 2023, Номер 35(4), С. 108836 - 108836

Опубликована: Июль 26, 2023

Язык: Английский

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