Journal of Molecular Structure, Год журнала: 2023, Номер 1299, С. 137217 - 137217
Опубликована: Дек. 1, 2023
Язык: Английский
Journal of Molecular Structure, Год журнала: 2023, Номер 1299, С. 137217 - 137217
Опубликована: Дек. 1, 2023
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(4), С. 2190 - 2199
Опубликована: Янв. 27, 2024
Ketenimines represent an important class of reactive species, useful synthetic intermediates, and synthons. However, in general, ketenimines preferentially undergoes nucleophilic addition reactions with hydroxyl amino groups, carbon functional groups remain a less studied subset such systems. Herein, we develop straightforward syntheses pyridin-4(1H)-imines that is achieved by cyclization reacting enaminone unit α-acylketenimine which generated from the sulfonyl azides terminal ynones situ (CuAAC/Ring cleavage reaction). The cascade process starts α-C instead group, attacking electron-deficient central ketenimine, chemoselectivity unconventional products were formed intramolecular cyclization.
Язык: Английский
Процитировано
5Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(29), С. 5897 - 5901
Опубликована: Янв. 1, 2024
Sulfonyl groups are motifs that widely found in biologically active compounds and drug molecules, many isolated natural products as well pharmaceuticals contain sulfonyl groups. Herein, we present the synthesis of sulfonyl-substituted isoindolones by a electrochemical oxidative radical cascade cycloaddition reaction olefinic amides with sodium sulfite under oxidant- catalyst-free conditions. Various sulfinates were compatible gave desired yields up to 99%.
Язык: Английский
Процитировано
3The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 28, 2025
A cobalt-catalyzed three-component cascade reaction for the synthesis of functionalized 5-amino-1,2,4-triazolo[1,5-c]quinazoline derivatives is presented. The involves ortho-cyanoaryl isocyanides, azides, and hydrazides, giving products in good to excellent yields. protocol highly scalable, as demonstrated by a gram-scale bioactive CGS-15943, providing robust, efficient method synthesizing triazoloquinazoline offering significant potential drug discovery further modifications.
Язык: Английский
Процитировано
0Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(6), С. 1775 - 1781
Опубликована: Янв. 1, 2024
We have successfully demonstrated an efficient and practical Pd-catalyzed reaction between aziridine isocyanide, leading to the synthesis of isoindoline derivatives in moderate good yields.
Язык: Английский
Процитировано
2Chemical Communications, Год журнала: 2024, Номер 60(21), С. 2950 - 2953
Опубликована: Янв. 1, 2024
A convenient and straight-forward entry to pyrrole[2,3- b ]indoles ureas via ligand-controlled palladium-catalyzed chemoselective tandem reaction of 2-ethynylanilines isocyanides has been established.
Язык: Английский
Процитировано
2Chinese Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 20, 2024
Comprehensive Summary Herein, a [1,2]‐phospha‐Brook rearrangement‐initiated palladium‐catalyzed cyclization reaction for base‐controlled selective synthesis of 2 H ‐isoindole‐1‐carboxamide and ‐isoindole‐1‐carbonitrile derivatives has been described. This strategy features double isocyanide insertion, efficient bond combinations, simple operation conditions. Mechanistic studies show that the rearrangement is key step in this reaction. protocol offers novel concise ‐isoindole derivatives.
Язык: Английский
Процитировано
2Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
A palladium-catalyzed cascade cyclization reaction of di-
Язык: Английский
Процитировано
1Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(21), С. 3611 - 3615
Опубликована: Сен. 14, 2023
Abstract Herein, a copper‐catalyzed photoinduced [3+3] cycloaddition reaction of α‐acidic isocyanides with 2,5‐diaryltetrazoles is described. The proceeded smoothly high regioselectivity, affording range important 1,2,4‐triazines under mild conditions. obtained were converted into triazine alcohol, Weinreb amide and triazinone easily, which further illustrate the utility this process.
Язык: Английский
Процитировано
3Chinese Journal of Chemistry, Год журнала: 2023, Номер 42(3), С. 259 - 263
Опубликована: Сен. 21, 2023
Comprehensive Summary A series of 3‐acyl‐substituted isoindolinone derivatives were synthesized in a one‐pot manner via the reaction o ‐bromobenzaldehydes, isocyanides, and carboxylic acids presence palladium catalyst base. The employing easily available starting materials features simple operation high efficiency. mechanistic study showed that might undergo 1) Pd‐catalyzed [3+2] cyclization ‐bromobenzaldehyde with isocyanide re‐insertion another molecule isocyanide, 2) addition acid to situ formed ketenimine followed by rearrangement relay give 3,3‐diacyl‐substituted derivative. Further transformations obtained products through decarbonylation could also be realized.
Язык: Английский
Процитировано
2Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(20), С. 5868 - 5875
Опубликована: Янв. 1, 2024
We presented metal-free cascade reactions of isocyanides with 3-methyleneoxindoles and 3-methylenebenzofuranones via the cleavage chemically inert carbon–nitrogen bond or carbon–oxygen bond.
Язык: Английский
Процитировано
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