Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
A
photocatalytic
methodology
has
been
devised
for
the
stereoselective
construction
of
trisubstituted
alkenes
incorporating
3,3‐difluoro‐γ‐lactams
in
17–93%
yields
via
a
radical
cascade
process
utilizing
MBH
acetates
and
N
‐allylbromodifluoroacetamides
as
starting
materials.
The
reaction
mechanism
involves
single‐electron
transfer,
5
‐
exo
trig
cyclization,
addition,
elimination
fashion.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(16), С. 11874 - 11884
Опубликована: Авг. 3, 2023
A
direct
arylsulfonylation
of
β,γ-unsaturated
hydrazones
method,
in
which
sulfonated
pyrazolines
are
accessed
by
a
three-component
reaction
hydrazones,
DABSO,
and
aryldiazonium
tetrafluoroborates,
has
been
developed
without
external
oxidants
or
catalysts.
This
transformation
is
triggered
the
formation
arylsulfonyl
radicals
situ
from
tetrafluoroborates
enabled
controllable
generation
C
center
radical,
DABSO
was
utilized
as
sulfone
source
an
oxidant
this
radical-mediated
cascaded
reaction.
wide
range
substrates
can
be
applied
process
to
afford
good
yield,
it
amenable
for
gram-scale
synthesis.
Organic Letters,
Год журнала:
2023,
Номер
25(40), С. 7322 - 7326
Опубликована: Окт. 4, 2023
A
simple
and
efficient
Pd-catalyzed
oxidative
cyclization
system
is
developed
for
the
chemo-
regioselective
synthesis
of
3,4-dihydro-benzothiadiazine
1,1-dioxides,
which
are
formed
through
aminosulfonylation
ortho-iodoanilines
with
SO2.
DABSO
utilized
as
source
SO2,
organic
compound
O2
acts
an
oxidant.
This
direct
C-S,
S-N,
C-N
functionalization
highly
efficient,
broad
functional
group
tolerance
observed,
resulting
in
moderate
to
excellent
yields
1,1-dioxides.
Furthermore,
this
method
amenable
gram-scale
synthesis.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Март 26, 2024
The
first
photocatalytic
trichloromethyl
radical-triggered
annulative
reactions
of
amide-linked
1,7-diynes
with
polyhalomethanes
were
established
for
the
flexible
assembly
functionalized
quinolin-2(1H)-ones
generally
acceptable
yields.
With
installation
aryl
group
(R
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
We
report
an
efficient
photocatalytic
protocol
for
the
defluorocyanoalkylation
and
defluoroacylation
of
α-trifluoromethyl
styrenes
by
utilizing
oxime
esters
as
radical
donors,
allowing
preparation
diverse
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(12), С. 3010 - 3015
Опубликована: Янв. 1, 2023
A
new
cobalt-catalyzed
hydroazidation
of
1-aryl-1,3-dienes
by
using
TMSN
3
as
a
nucleophilic
azide
source
under
mild
conditions
has
been
reported,
leading
to
the
synthesis
wide
range
allylic
azides
with
moderate
good
yields.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(25), С. 5240 - 5244
Опубликована: Янв. 1, 2023
A
visible-light
irradiation
tandem
oxidative
aryl
migration/carbonyl
formation
reaction,
mediated
by
K
2
S
O
8
and
photoredox
catalysis,
has
been
discovered.
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3620 - 3620
Опубликована: Июль 31, 2024
Synthetic
radicals
have
intrinsic
power
for
cascading
and
multifunctional
reactions
to
construct
diverse
molecular
scaffolds.
In
the
previous
review
series,
we
covered
1,2-difunctionalizations,
remote
1,3-,
1,4-,
1,5-,
1,6-,
1,7-difunctionalizations,
addition
followed
by
cyclization
reactions,
cycloaddition-initiated
difunctionalizations.
Presented
in
this
paper
are
radical
addition-initiated
trifunctionalization
of
alkenes,
alkynes,
their
derivatives.
After
initial
addition,
there
different
pathways,
such
as
group
or
hydrogen
atom
transfer,
cyclization,
coupling,
complete
second
third
functionalizations.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(21), С. 15901 - 15913
Опубликована: Окт. 12, 2024
A
novel
and
robust
alkynylation
of
C(sp3)–H
bonds
adjacent
to
a
nitrogen
atom
tertiary
amines
with
alkynyl
bromides
as
radical
alkynylating
reagents
has
been
realized
under
visible-light
irradiation.
range
variety
including
N-arylamines
N-alkylamine
have
coupled
both
aromatic
aliphatic
furnish
51
examples
propargylamines
in
moderate
excellent
yields
(31–80%
yields).
The
possible
mechanism
was
addition–elimination
process
based
on
preliminary
mechanistic
studies.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
A
photocatalytic
methodology
has
been
devised
for
the
stereoselective
construction
of
trisubstituted
alkenes
incorporating
3,3‐difluoro‐γ‐lactams
in
17–93%
yields
via
a
radical
cascade
process
utilizing
MBH
acetates
and
N
‐allylbromodifluoroacetamides
as
starting
materials.
The
reaction
mechanism
involves
single‐electron
transfer,
5
‐
exo
trig
cyclization,
addition,
elimination
fashion.
