Visible Light-Induced Copper-Catalyzed Regio- and Stereoselective Difluoroalkylthiocyanation of Alkynes

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 9118 - 9124

Опубликована: Июнь 6, 2024

The first regio- and stereoselective difluoroalkylthiocyanation of alkynes with BrCF

Язык: Английский

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Photoinduced Metal-Free Radical Addition/Cyclization of 2-Cyanoaryl Acrylamides to Prepare gem-Difluorinated Naphthyridinone Scaffolds

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10831 - 10843

Опубликована: Июль 11, 2024

Direct construction of

Язык: Английский

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A metal-free strategy to construct fluoroalkyl–olefin linkages using fluoroalkanes

Chemical Science, Год журнала: 2023, Номер 15(5), С. 1752 - 1757

Опубликована: Дек. 22, 2023

We report a metal-free strategy to access fluoroalkyl–olefin linkages from RCF 2 H (R = aryl, H, F and fluoroalkyl) precursors vinyl-pinacol boronic ester (BPin) reagents.

Язык: Английский

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Dual Photoredox/Nickel-Catalyzed Dehydrative Difluoroalkylation of Benzyl Alcohols for the Synthesis of Allylic gem-Difluorides

Organic Letters, Год журнала: 2023, Номер 25(35), С. 6511 - 6516

Опубликована: Авг. 28, 2023

A photoredox/Lewis acid cooperative catalytic system has been developed for the construction of Cvinyl–CRf bonds through dehydrative difluoroalkylation benzyl alcohols. variety allylic gem-difluorides could be obtained in moderate yields with good to excellent E/Z selectivity. In addition, several control experiments have explored, and a possible mechanism was proposed this process.

Язык: Английский

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Oxy-difluoroallylation of Ynamides by Nickel-Catalyzed Tandem Alkoxylation/Claisen Rearrangement

Organic Letters, Год журнала: 2024, Номер 26(41), С. 8832 - 8836

Опубликована: Окт. 9, 2024

A nickel-catalyzed tandem alkoxylation/claisen rearrangement strategy for the oxy-difluoroallylation of ynamides has been developed. In this reaction, 3,3-difluoroallyl alcohol was used as a fluorine-containing building block to construct C–CF2 bond first time. This approach is recognized its robust tolerance functional groups, impressive yields, and excellent atomic efficiency, all achieved under mild reaction conditions. series β,β-difluoromethyleneamide derivatives were efficiently obtained through simple operations, their practicality confirmed gram-scale synthesis product derivatization.

Язык: Английский

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Modular Synthesis of gem-Difluorotetrahydrocarbazolone Scaffolds via Copper-Catalyzed Cascade Reaction of Bromodifluoroacetyl Indoles and Olefins

Organic Letters, Год журнала: 2024, Номер 26(42), С. 9085 - 9090

Опубликована: Окт. 16, 2024

A novel and efficient modular synthesis of

Язык: Английский

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Visible-light-induced three component difluoromethylation cyclization carbo-thioesterification to CF2-Containing γ-Lactams

Molecular Catalysis, Год журнала: 2024, Номер 570, С. 114685 - 114685

Опубликована: Ноя. 21, 2024

Язык: Английский

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