Modular Synthesis of gem-Difluorotetrahydrocarbazolone Scaffolds via Copper-Catalyzed Cascade Reaction of Bromodifluoroacetyl Indoles and Olefins DOI

Qianhui Yu,

Qingyu Luo,

Yu-Hang Ye

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9085 - 9090

Published: Oct. 16, 2024

A novel and efficient modular synthesis of

Language: Английский

Visible Light-Induced Copper-Catalyzed Regio- and Stereoselective Difluoroalkylthiocyanation of Alkynes DOI

Xiaoxue Hu,

Yanzhao Wang, Shibo Xu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(12), P. 9118 - 9124

Published: June 6, 2024

The first regio- and stereoselective difluoroalkylthiocyanation of alkynes with BrCF

Language: Английский

Citations

1
Photoinduced Metal-Free Radical Addition/Cyclization of 2-Cyanoaryl Acrylamides to Prepare gem-Difluorinated Naphthyridinone Scaffolds DOI

Qiaoyan Wu,

Meilin Ren,

Zhike Zhou

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10831 - 10843

Published: July 11, 2024

Direct construction of

Language: Английский

Citations

1
A metal-free strategy to construct fluoroalkyl–olefin linkages using fluoroalkanes DOI Creative Commons
Kaushik Chakrabarti, Michael M. Wade Wolfe, Shuo Guo

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 15(5), P. 1752 - 1757

Published: Dec. 22, 2023

We report a metal-free strategy to access fluoroalkyl–olefin linkages from RCF 2 H (R = aryl, H, F and fluoroalkyl) precursors vinyl-pinacol boronic ester (BPin) reagents.

Language: Английский

Citations

3
Dual Photoredox/Nickel-Catalyzed Dehydrative Difluoroalkylation of Benzyl Alcohols for the Synthesis of Allylic gem-Difluorides DOI

Yu-Yang Bai,

Liping Cao, Siyuan Li

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(35), P. 6511 - 6516

Published: Aug. 28, 2023

A photoredox/Lewis acid cooperative catalytic system has been developed for the construction of Cvinyl–CRf bonds through dehydrative difluoroalkylation benzyl alcohols. variety allylic gem-difluorides could be obtained in moderate yields with good to excellent E/Z selectivity. In addition, several control experiments have explored, and a possible mechanism was proposed this process.

Language: Английский

Citations

2
Oxy-difluoroallylation of Ynamides by Nickel-Catalyzed Tandem Alkoxylation/Claisen Rearrangement DOI

Haotian Gao,

Tiebo Xiao,

Yubo Jiang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(41), P. 8832 - 8836

Published: Oct. 9, 2024

A nickel-catalyzed tandem alkoxylation/claisen rearrangement strategy for the oxy-difluoroallylation of ynamides has been developed. In this reaction, 3,3-difluoroallyl alcohol was used as a fluorine-containing building block to construct C–CF2 bond first time. This approach is recognized its robust tolerance functional groups, impressive yields, and excellent atomic efficiency, all achieved under mild reaction conditions. series β,β-difluoromethyleneamide derivatives were efficiently obtained through simple operations, their practicality confirmed gram-scale synthesis product derivatization.

Language: Английский

Citations

0
Visible-light-induced three component difluoromethylation cyclization carbo-thioesterification to CF2-Containing γ-Lactams DOI

Dan Shao,

Tingting Yu,

Lianglong Sun

et al.

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 570, P. 114685 - 114685

Published: Nov. 21, 2024

Language: Английский

Citations

0
Modular Synthesis of gem-Difluorotetrahydrocarbazolone Scaffolds via Copper-Catalyzed Cascade Reaction of Bromodifluoroacetyl Indoles and Olefins DOI

Qianhui Yu,

Qingyu Luo,

Yu-Hang Ye

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9085 - 9090

Published: Oct. 16, 2024

A novel and efficient modular synthesis of

Language: Английский

Citations

0