Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Comprehensive
Summary
Presented
herein
is
a
condition‐controlled
selective
synthesis
of
CF
3
‐chromene
and
‐benzofuran
based
on
the
reaction
N
‐phenoxyacetamide
‐ynone.
When
carried
out
in
MeOH
under
catalysis
Rh(III),
formed
via
C—H
metalation‐initiated
alkenylation,
acetamide
group
migration
intramolecular
oxo
‐nucleophilic
addition.
On
other
hand,
when
run
DMSO
promotion
CsOAc,
generated
aza
‐Michael
addition‐initiated
[3,3]‐σ
rearrangement,
addition
water
elimination.
To
our
knowledge,
this
first
report
construction
chromene
or
benzofuran
scaffold
along
with
introduction
unit
from
same
starting
materials.
The
methodology
was
scalable
products
could
be
readily
transformed
into
valuable
products.
Moreover,
thus
obtained
possess
decent
anticancer
activity.
Organic Letters,
Год журнала:
2024,
Номер
26(7), С. 1393 - 1398
Опубликована: Фев. 12, 2024
We
disclose
herein
a
photocatalytic
radical
cascade
cyclization
of
diazoalkanes
for
the
divergent
synthesis
important
carbocycles
and
heterocycles.
Under
optimal
reaction
conditions,
various
indanone,
pyrone,
pyridinone
derivatives
can
be
obtained
in
moderate
to
good
yields.
Mechanistic
experiments
support
formation
carbon-centered
radicals
from
through
proton-coupled
electron
transfer
process.
Scale-up
using
continuous
flow
technology
useful
downstream
application
formed
heterocycles
further
render
strategy
attractive
valuable.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(19), С. 2346 - 2350
Опубликована: Май 27, 2024
Comprehensive
Summary
Catalytic
and
green
strategies
for
the
synthesis
of
privileged
scaffolds
are
synthetically
appealing.
We
now
report
a
radical‐polar
crossover
(RPC)‐enabled
three‐component
cyclization
bromodifluoroalkyls
with
enaminones
6‐aminouraciles
via
visible‐light‐induced
domino
cyclization.
The
reaction
exhibited
broad
substrate
scope
(>
40
examples)
including
complex
molecules,
which
highlighted
utility
this
strategy
construction
library
bioactive
analogs.
ACS Omega,
Год журнала:
2024,
Номер
9(26), С. 28129 - 28143
Опубликована: Июнь 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(17), С. 2888 - 2893
Опубликована: Июль 25, 2023
Abstract
A
I
2
‐DMSO
mediated
approach
to
introduce
−OCD
3
into
pyrroles
in
situ
via
multicomponent
cascade
cyclization
reaction
using
methyl
ketones,
aniline,
ethyl
benzoylacetate
and
CD
OD
as
readily
available
substrates
is
reported.
This
process
realizes
introduction
of
the
Hantzsch
pyrrole
synthesis
deuterated
alkoxy‐substituted
with
formation
one
C−C
bond,
C−O
bond
two
C−N
bonds
pot.
Notably,
this
conversion
has
good
substrate
compatibility
(62
examples)
eliminates
need
for
anhydrous
anaerobic
operation.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 3403 - 3412
Опубликована: Фев. 8, 2024
A
practical
and
efficient
copper-catalyzed
carbocyclization
of
2-functionalized
anilines
with
ethyl
bromodifluoroacetate
has
been
developed.
Ethyl
is
employed
as
the
C1
source
via
quadruple
cleavage
in
this
transformation.
This
reaction
can
afford
a
variety
N-containing
heterocyclics
satisfactory
yields
excellent
functional
group
compatibility.
