Cu(II)-Mediated Sulfonylation of (Hetero)arenes with TosMIC Using Monodentate Directing Groups DOI

Yigao Li,

Zhuang Meng, Xinju Zhu

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(6), С. 3894 - 3906

Опубликована: Фев. 22, 2024

Monodentate chelation-assisted direct ortho-C–H sulfonylation of (hetero)arenes using TosMIC as the novel sulfonylating reagent has been developed. A broad range substrates, including indolines, indoles, 2-phenylpyridines, and others were well tolerated to afford corresponding products in moderate good yields. Mechanistic studies revealed that sulfonyl radical might be involved. Inspired by above discovery, preliminary para-C–H naphthalene substrate was also successfully realized. The current protocol featured with cheap metal catalysis, functional group compatibility, operational convenience.

Язык: Английский

Synthesis of Naphtho[1′,2′:4,5]furo[3,2-b]pyridinones via Ir(III)-Catalyzed C6/C5 Dual C–H Functionalization of N-Pyridyl-2-pyridones with Diazonaphthalen-2(1H)-ones DOI
Yuanshuang Xu,

Yujing Xiao,

Xinying Zhang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(4), С. 786 - 791

Опубликована: Янв. 22, 2024

Presented herein is an unprecedented synthesis of naphtho[1′,2′:4,5]furo[3,2-b]pyridinones via Ir(III)-catalyzed C6/C5 dual C–H functionalization N-pyridyl-2-pyridones with diazonaphthalen-2(1H)-ones. This protocol forms C–C and C–O bonds in one pot which diazonaphthalen-2(1H)-ones serve as bifunctional reagents, providing both alkyl aryloxy sources. To the best our knowledge, this first example title compounds by using substrates. Notably, method features operational simplicity, good functional group tolerance, high efficiency, atom economy.

Язык: Английский

Процитировано

8
Electrochemical Sulfonylation/Cyclization of N-Alkenylacrylamides with Sodium Sulfinates or Sulfonyl Hydrazides DOI
Zhixian Yang,

Lu-Cai Ding,

Gui-Hong Yang

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10660 - 10677

Опубликована: Июль 18, 2024

Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of

Язык: Английский

Процитировано

8
Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections DOI Creative Commons
Assunta D’Amato, Annaluisa Mariconda, Domenico Iacopetta

и другие.

Pharmaceuticals, Год журнала: 2023, Номер 16(12), С. 1729 - 1729

Опубликована: Дек. 15, 2023

Poor responses to medical care and the failure of pharmacological treatment for many high-frequency diseases, such as cancer viral infections, have been widely documented. In this context, numerous metal-based substances, including cisplatin, auranofin, various gold metallodrugs, ruthenium complexes, are under study possible anticancer antiviral agents. The two Ru(III) Ru(II) namely, BOLD-100 RAPTA-C, presently being studied in a clinical trial preclinical studies evaluation, respectively, Interestingly, has also recently demonstrated activity against SARS-CoV-2, which is virus responsible COVID-19 pandemic. Over last years, much effort dedicated discovering new dual anticancer-antiviral Ru-based complexes could be very suitable respect. Thus, review focuses on most recent regarding newly synthesized use and/or

Язык: Английский

Процитировано

15
Recent advances in selective mono-/dichalcogenation and exclusive dichalcogenation of C(sp2)–H and C(sp3)–H bonds DOI
Chang‐Sheng Wang, Yuan Xu, Shaopeng Wang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 22(4), С. 645 - 681

Опубликована: Дек. 23, 2023

Organochalcogen compounds are prevalent in numerous natural products, pharmaceuticals, agrochemicals, polymers, biological molecules and synthetic intermediates. Direct chalcogenation of C-H bonds has evolved as a step- atom-economical method for the synthesis chalcogen-bearing compounds. Nevertheless, direct severely lags behind C-C, C-N C-O bond formations. Moreover, compared with monochalcogenation, reports selective mono-/dichalcogenation exclusive dichalcogenation relatively scarce. The past decade witnessed significant advancements various C(sp

Язык: Английский

Процитировано

10
Copper-Catalyzed Regioselective Imidation of 2-Pyridones DOI

Tamilarasu Murugesan,

Shanawas Hussain Moulana Mahal,

Kalyanakrishnan Arayil Vennoli

и другие.

Organic Letters, Год журнала: 2024, Номер 26(15), С. 3048 - 3053

Опубликована: Апрель 5, 2024

We demonstrate a ligand- and glovebox-free regioselective direct C(3)–H imidation of 2-pyridones also benzylic-type bearing methyl substituent employing Cu(OAc)2·H2O as the catalyst N-fluorobenzenesulfonimide (NFSI) an imidating reagent. A broad range imidated 2-pyridone derivatives is made up to excellent yields. The present strategy operates well on gram scale, ensuing product can be readily subjected mono- bis-desulfonylation reactions.

Язык: Английский

Процитировано

4
Ruthenium-based macrocyclic and Schiff base complexes as prominent therapeutic agents: Their designing, synthesis and recent perspectives DOI

Urmila Phageria,

Sushama Kumari,

Krishna Atal

и другие.

Polyhedron, Год журнала: 2024, Номер 266, С. 117309 - 117309

Опубликована: Ноя. 17, 2024

Язык: Английский

Процитировано

1
Cu(II)-Mediated Sulfonylation of (Hetero)arenes with TosMIC Using Monodentate Directing Groups DOI

Yigao Li,

Zhuang Meng, Xinju Zhu

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(6), С. 3894 - 3906

Опубликована: Фев. 22, 2024

Monodentate chelation-assisted direct ortho-C–H sulfonylation of (hetero)arenes using TosMIC as the novel sulfonylating reagent has been developed. A broad range substrates, including indolines, indoles, 2-phenylpyridines, and others were well tolerated to afford corresponding products in moderate good yields. Mechanistic studies revealed that sulfonyl radical might be involved. Inspired by above discovery, preliminary para-C–H naphthalene substrate was also successfully realized. The current protocol featured with cheap metal catalysis, functional group compatibility, operational convenience.

Язык: Английский

Процитировано

0