Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173
Опубликована: Янв. 1, 2024
Язык: Английский
Organic Letters, Год журнала: 2024, Номер 26(29), С. 6197 - 6202
Опубликована: Июль 15, 2024
A silver-promoted three-component heterocyclization of alkynes, perfluoroalkyl halides, and 1,3-dinucleophiles was developed for the efficient synthesis privileged (E)-perfluoroalkenyl pyrroles. The reaction proceeded through a rationally designed sequence radical perfluoroalkylation intramolecular defluorinative [3 + 2]-heterocyclization. utility halide as perfluoroalkenyl reagent, by selective controllable functionalization two inert C(sp3)–F bonds at vicinal carbon centers on chain, provides new mode value-added organofluorides starting from easily available low-cost fluorinated feedstock.
Язык: Английский
Процитировано
11
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(14), С. 3974 - 3981
Опубликована: Янв. 1, 2024
A defluorinative cyclization of readily available trifluoromethyl enones with phosphine oxides for the synthesis polysubstituted furans is developed in a pure water solution.
Язык: Английский
Процитировано
9
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(5), С. 1444 - 1449
Опубликована: Янв. 1, 2024
A visible-light-promoted desulfonylative radical difluoroalkylation between difluoroenol silyl ethers and difluoroalkyl sulfones has been developed.
Язык: Английский
Процитировано
8
Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Дек. 24, 2024
A three-component reaction of trifluoromethyl enones, phosphine oxides, and alcohols in water solution is developed. This defluorinative occurs through a cascade process involving defluorophosphorylation, defluoroalkyloxylation, defluoroheteroannulation, enabling the modular synthesis furans with four distinct substituents: C2-alkyloxy, C3-trifluoromethyl, C4-phosphoryl, C5-(hetero)aryl groups. Moreover, apart from alcohol substrates, scope nucleophiles could be further extended to phenols, azacycles, or sulfonamide.
Язык: Английский
Процитировано
6
Green Chemistry, Год журнала: 2023, Номер 25(23), С. 9672 - 9679
Опубликована: Янв. 1, 2023
A H 2 O-promoted and (NH 4 ) CO 3 -enabled defluoroiminization reaction of fluoroalkyl alkenes for the synthesis fluoroalkylated 1,5-diazapentadienes has been developed.
Язык: Английский
Процитировано
15
Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(4), С. 1045 - 1045
Опубликована: Янв. 1, 2024
Transition-metal-catalyzed cycloadditions have been evolved as important and efficient methods to construct cyclic molecules.Among them, transition-metal-catalyzed using carbon monoxide (CO) gas the 1C synthon provide their unique powerful approaches build various molecules within a carbonyl group, which either acts an functional group cycloadducts, or can be further elaborated other groups.The tremendous advances in this field are introduced.
Язык: Английский
Процитировано
5
The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Сен. 25, 2024
A straightforward preparation of diversified fluorinated indol-3-yl ketones was developed by the direct decarboxylative fluoroacylation indole carboxylic acids. The reaction could be performed on a gram scale under net conditions. Neither metal catalyst nor an additive employed. This methodology featured simple conditions, high efficiency, exclusive selectivity, broad substrate scope, and easy operation, which allowed it to meet green chemistry requirement modern pharmaceutical industry. Control experiments confirmed that radical process might involved in tandem sequence.
Язык: Английский
Процитировано
2
European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Окт. 16, 2024
Abstract A method for the synthesis of symmetrical and unsymmetrical 3,3′‐bis(indolyl)methanes (3,3′‐BIMs) has been developed through direct heteroarylation indolyl‐containing di(hetero)aryl phosphonium salts with indole derivatives in aqueous media. This metal‐free reaction proceeds smoothly under mild conditions, eliminating need hazardous solvents expensive additives/catalysts typically used conventional routes, thereby highlighting synthetic practicality efficiency process. The success this approach is largely attributed to role water as a promoter, facilitating C−P bond functionalization salts. Furthermore, demonstrates broad substrate scope, good functional group tolerance, excellent scalability. Moreover, protocol can also be extended triindolylmethane compound diarylmethylated indole.
Язык: Английский
Процитировано
1
ChemistrySelect, Год журнала: 2024, Номер 9(36)
Опубликована: Сен. 19, 2024
Abstract Indole motifs are omnipresent in nature and can be found many natural products as well pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic interest the organic medicinal chemist community decades. In review, we emphasized functionalization indoles via transition‐metal‐free approaches. This review touches on aspects different sub‐sections, which gives proposition tactics employed an overview road ahead.
Язык: Английский
Процитировано
0
Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0