Abstract
(Trifluoromethyl)sulfanyl
compounds
have
garnered
significant
attention
in
medicinal
chemistry,
agrochemistry,
and
materials
science
due
to
their
unique
physicochemical
properties,
including
high
lipophilicity,
metabolic
stability,
strong
electron-withdrawing
ability.
This
review
pro-vides
a
comprehensive
overview
of
the
current
methods
for
synthesis
(trifluoromethyl)sulfanyl
compounds,
highlighting
recent
advances
emerging
strategies.
Key
synthetic
approaches,
such
as
direct
(trifluoromethyl)sulfanylation,
transition-metal-catalyzed
processes,
radical-based
are
discussed
with
an
emphasis
on
substrates
reagents.
The
chapter
also
briefly
introduces
mechanistic
insights
role
novel
reagents
enhancing
efficiency
selectivity
these
transformations.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(11), С. 2607 - 2612
Опубликована: Март 26, 2024
Abstract
Transition‐metal
catalyzed
difunctionalization
of
olefins
has
attracted
considerable
attention
as
a
method
to
construct
carbon‐carbon
and
carbon‐hetero
bonds.
Herein,
the
copper‐catalyzed
three‐component
radical
cross‐coupling
oxime
esters,
styrenes
AgSCF
3
through
visible‐light‐promoted
iminyl
radical‐mediated
bond
cleavage
strategy
been
described.
Utilizing
low‐cost
copper
salt
both
photosensitizers
cross‐couplers,
this
protocol
delivers
diverse
target
products,
providing
supplementary
approach
for
cyanoalkylation
trifluoromethylthiolation
drug
molecules.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(20), С. 5851 - 5858
Опубликована: Янв. 1, 2024
A
novel
palladium-catalyzed
four-component
domino
sulfonylation
and
carbonylation
of
1,3-enynes
has
been
developed,
which
enables
the
rapid
incorporation
allene,
sulfone,
carbonyl
amine
units
into
one
single
molecule
simultaneously.
Reaction Chemistry & Engineering,
Год журнала:
2024,
Номер
10(3), С. 500 - 510
Опубликована: Дек. 20, 2024
Multicomponent
reactions
(MCRs)
have
become
excellent
tools
for
synthesizing
complex
and
high-value
molecules.
This
minireview
highlights
recent
progresses
in
MCRs
classified
by
the
type
of
catalysts
to
offer
a
better
deeper
understanding.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(13), С. 3589 - 3595
Опубликована: Янв. 1, 2024
This
method
offers
a
simple,
effective
pathway
for
synthesizing
diverse
β-keto
sulfonamides
with
satisfactory
yields
under
mild
conditions,
showing
broad
substrate
compatibility
and
good
tolerance
towards
various
functional
groups.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 4740 - 4747
Опубликована: Янв. 1, 2024
The
Reppe
sulfonylation
reaction
has
remained
substantially
underexplored.
We
present
a
novel
method
for
involving
SO
2
insertion,
remarkably
without
the
need
metal
catalysts,
instead
utilizing
Brønsted
bases
as
catalysts.
Abstract
(Trifluoromethyl)sulfanyl
compounds
have
garnered
significant
attention
in
medicinal
chemistry,
agrochemistry,
and
materials
science
due
to
their
unique
physicochemical
properties,
including
high
lipophilicity,
metabolic
stability,
strong
electron-withdrawing
ability.
This
review
pro-vides
a
comprehensive
overview
of
the
current
methods
for
synthesis
(trifluoromethyl)sulfanyl
compounds,
highlighting
recent
advances
emerging
strategies.
Key
synthetic
approaches,
such
as
direct
(trifluoromethyl)sulfanylation,
transition-metal-catalyzed
processes,
radical-based
are
discussed
with
an
emphasis
on
substrates
reagents.
The
chapter
also
briefly
introduces
mechanistic
insights
role
novel
reagents
enhancing
efficiency
selectivity
these
transformations.
