Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(9)
Опубликована: Июль 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
Organic Letters,
Год журнала:
2024,
Номер
26(6), С. 1249 - 1254
Опубликована: Фев. 2, 2024
An
efficient
copper
catalytic
system
has
been
established
for
the
synthesis
of
highly
functional
indolizines
through
oxidative
[3
+
2]
cycloaddition
enamines
and
pyridotriazoles.
This
modular
platform
is
compatible
with
a
broad
range
groups,
including
natural
complex
skeletons,
allowing
late-stage
modifications.
It
features
step-economical,
regioselective,
easy-handling
procedure
applied
in
constructing
small
molecules
potent
activity
toward
inhibiting
VEGF–NRP1
interaction
one-pot
reaction
pyridotriazoles,
amines,
aldehydes.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(19), С. 4139 - 4144
Опубликована: Июль 2, 2024
Abstract
A
copper‐catalyzed
annulation
of
enaminones
with
maleimides
was
developed
to
synthesize
various
pyrrolo[3,4‐e]isoindoles.
In
this
strategy,
2‐aminopyridine
served
as
a
traceless
directing
group,
and
target
products
were
obtained
in
54–72%
yields.
Moreover,
plausible
mechanism
for
reaction
proposed
based
on
several
control
experiments,
deuterium
exchange
previous
reports.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(13), С. 9496 - 9501
Опубликована: Июнь 18, 2024
Herein,
an
unprecedented
[4
+
2]
cycloaddition
of
enaminone
with
1,3,5-triazinane
has
been
developed.
The
representative
semihydrogenated
aromatic
heterocycle
1,2,3,4-tetrahydropyrimidines
have
synthesized
a
broad
substrate
scope,
demonstrating
potential
antitumor
activity.
This
approach
smoothly
conducted
under
additive-free
and
environmentally
friendly
conditions
that
are
compatible
various
functional
groups.
Furthermore,
the
condition
optimization
process
reveals
tetrahydropyrimidine
product
is
regulated
via
reaction
temperature.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(9)
Опубликована: Июль 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
