The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(12), С. 8721 - 8733
Опубликована: Июнь 4, 2024
A
novel
strategy
for
the
difunctionalization
of
electron-deficient
alkenes
with
aryl
sulfonium
salts
to
access
remote
sulfur-containing
oxindole
derivatives
by
using
in
situ-formed
copper(I)-based
complexes
as
a
photoredox
catalyst
is
presented.
This
method
enables
generation
C(sp3)-centered
radicals
through
site
selective
cleavage
C–S
bond
under
mild
conditions.
Moreover,
oxidation
reactions
desired
products
provide
new
preparation
sulfoxide
or
sulfone-containing
compounds.
Importantly,
this
approach
can
be
easily
applied
late-stage
modification
pharmaceuticals
molecules.
Chemical Communications,
Год журнала:
2024,
Номер
60(42), С. 5502 - 5505
Опубликована: Янв. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(16), С. 1913 - 1928
Опубликована: Апрель 24, 2024
Comprehensive
Summary
Organic
fluorine
compounds
are
ubiquitous
and
pivotally
important
organic
molecules,
yet
their
activation
transformation
have
long
been
a
formidable
challenge
due
to
the
high
energy
low
reactivity
of
C—F
bonds.
electrosynthesis,
an
environmentally
benign
synthetic
method
in
chemistry,
enables
myriad
chemical
transformations
without
need
for
external
redox
reagents.
In
recent
years,
electrochemistry
has
emerged
as
powerful
tool
achieving
bonds
fluorine‐containing
compounds.
This
review
aims
succinctly
recapitulate
latest
advancements
electrochemical
defluorinative
delve
into
reaction
design,
mechanistic
insights,
developmental
prospects
these
methods.
Key
Scientists
1959,
Lund
was
first
pioneer
electroreduction
CF
3
CH
group.
Electrochemistry
lately
provided
new
opportunities
efficient
conversion
fluorides.
2020,
Zhou
coworkers
discovered
carboxylation
α‐CF
alkenes.
Lambert
colleagues
reported
electrophotocatalytic
amination
aryl
Electrochemical
hydrodefluorination
trifluoromethylketones
developed
by
Lennox
2021.
same
year,
Wang
Guo
disclosed
radical
alkylation
alkenes
with
Katritzky
salts
alkyl
precursors.
Subsequently,
Wu
Liao
described
transition‐metal‐free,
site‐selective
arylation
polyfluoroarenes
(het)arenes
using
paired
electrophotocatalysis.
2023,
numerous
efforts
were
made
achieve
bond
activation.
Xia
organoboron‐controlled
chemoselective
sequential
(deutero)hydrodefluorination
trifluoroacetamides.
Saudi Pharmaceutical Journal,
Год журнала:
2023,
Номер
31(12), С. 101874 - 101874
Опубликована: Ноя. 22, 2023
Novel
α-amylase
inhibitors
play
a
crucial
role
in
managing
diabetes
and
obesity,
contributing
to
improved
public
health
by
addressing
these
challenging
prevalent
conditions.
Moreover,
the
synthesis
of
anti-oxidant
agents
is
essential
due
their
potential
combating
oxidative
stress-related
diseases
promoting
overall
health.Synthesis
thoisemicarbazone
derivatives
2,4-dichlorophenyl
acetic
acid
screened
them
for
biological
activities.Thiosemicarbazone
(4-13)
were
synthesized
refluxing
with
sulfuric
ethanol
get
ester
(2),
which
was
further
refluxed
thiosemicarbazide
compound
(3).
Finally,
different
aromatic
aldehydes
(3)
catalytic
amount
obtained
final
products
(4-13).
Using
modern
spectroscopic
techniques
including
HR-ESI-MS,
13C-,
1H
NMR,
structures
created
confirmed.The
showed
excellent
good
inhibitory
activity
range
IC50
values
4.95
±
0.44
69.71
0.05
µM
against
enzyme
when
compared
standard
drug
acarbose
(IC50
=
21.55
1.31
µM).
In
case
iron
chelating
activity,
potent
better
than
EDTA
66.43
1.07
µM)
22.43
2.09
61.21
2.83
µM.
However,
also
show
28.30
1.17
64.66
2.43
hydroxyl
radical
scavenging
vitamin
C
60.51
1.02
DFT
used
calculate
reactivity
factors
ionization
potential,
electronegativity,
electron
affinity,
chemical
softness,
hardness
calculated
using
frontier
molecular
orbital
(FMO)
computations.
The
docking
studies
carried
out
AutoDock
Vina
understand
binding
affinities
active
sites
protein.
