Atroposelective catalysis

Nature Reviews Chemistry, Год журнала: 2024, Номер 8(7), С. 497 - 517

Опубликована: Июнь 18, 2024

Язык: Английский

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Dual Catalytic C(sp²)–H Activation of Azaheterocycles toward C–N Atropisomers

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 3700 - 3710

Опубликована: Фев. 14, 2025

Язык: Английский

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Chiral Amino Acids: Evolution in Atroposelective C-H Activation

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(25), С. 5032 - 5051

Опубликована: Янв. 1, 2024

This review covers the journey of chiral amino acids as ligands in atroposelective C–H bond activation/functionalization via transition metal catalysis.

Язык: Английский

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Synthesis of γ-Lactams via Palladium-Catalyzed C(sp³)–H Bond Activation of Alkyl Sulfonamides with Substituted Alkenes

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

A methodology for the γ-butyrolactam scaffolds via ligand-enabled C(sp3)–H bond functionalization of sulfonamides with olefins has been demonstrated. The protocol found to be compatible several activated and unactivated olefins, desired lactams were formed in excellent yields. plausible mechanism described account lactamization reaction as well supported by mechanistic investigation including a 1H NMR study isolation palladacycle intermediate.

Язык: Английский

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Ether-Directed Enantioselective C(sp²)–H Borylation for the Synthesis of Axially Chiral Biaryls

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

We report an ether-directed enantioselective C(sp2)-H borylation catalyzed by a chiral bidentate boryl ligand (CBL)/iridium system for constructing axially biaryls. This method delivered diverse biaryls with good to high enantioselectivities, accommodating varied electronic and steric substituents on the aryl rings. Gram-scale synthesis downstream transformations of C-B bond underscored its practicality.

Язык: Английский

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Oxidative Alkenylation of (Hetero)aromatics with Unactivated Alkenes: Control of the Reaction Selectivity

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(9), С. 1922 - 1949

Опубликована: Фев. 23, 2024

Abstract Alkenylbenzene skeletons represent one of the most widely occurring structural motifs in pharmaceutical drugs, natural products, and advanced materials. The construction alkenylbenzenes is promising through use a straightforward oxidative alkenylation protocol, particularly from unactivated alkenes. This significant because alkenes are inexpensive raw materials that can be obtained bulk quantities petrochemical feedstocks renewable resources. However, controlling reactivity regioselectivity olefination with unbiased olefins remains challenge, necessitating continuous efforts potentially having substantial impact on both organic synthesis industry. review aims to provide an overview latest advances regiocontrol strategies for reactions alkenes, which categorized into three types: 1) ligand‐promoted/accelerated reactions; 2) prefunctionalized olefins‐facilitated 3) directing group‐induced reactions.

Язык: Английский

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Palladium-Catalyzed Ligand-Enabled Cyclization of Substituted Aliphatic Carboxylic Acids with Allylic Electrophiles

Organic Letters, Год журнала: 2024, Номер 26(31), С. 6580 - 6585

Опубликована: Июль 25, 2024

A palladium-catalyzed cyclization of the β-C(sp

Язык: Английский

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Asymmetric 1,2-diaxial synthesis of bi-(hetero)aryl benzofulvene atropisomers via transient directing group-assisted dehydrogenative coupling

Chemical Communications, Год журнала: 2024, Номер 60(18), С. 2524 - 2527

Опубликована: Янв. 1, 2024

The efficient cross-dehydrogenative coupling of electronically rich and sterically congested benzofulvene with bi-(hetero)aryl moieties to construct an axially chiral core remains a formidable task.

Язык: Английский

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