Atroposelective catalysis

Nature Reviews Chemistry, Journal Year: 2024, Volume and Issue: 8(7), P. 497 - 517

Published: June 18, 2024

Language: Английский

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Dual Catalytic C(sp²)–H Activation of Azaheterocycles toward C–N Atropisomers

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3700 - 3710

Published: Feb. 14, 2025

Language: Английский

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Chiral Amino Acids: Evolution in Atroposelective C-H Activation

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(25), P. 5032 - 5051

Published: Jan. 1, 2024

This review covers the journey of chiral amino acids as ligands in atroposelective C–H bond activation/functionalization via transition metal catalysis.

Language: Английский

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Synthesis of γ-Lactams via Palladium-Catalyzed C(sp³)–H Bond Activation of Alkyl Sulfonamides with Substituted Alkenes

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

A methodology for the γ-butyrolactam scaffolds via ligand-enabled C(sp3)–H bond functionalization of sulfonamides with olefins has been demonstrated. The protocol found to be compatible several activated and unactivated olefins, desired lactams were formed in excellent yields. plausible mechanism described account lactamization reaction as well supported by mechanistic investigation including a 1H NMR study isolation palladacycle intermediate.

Language: Английский

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Ether-Directed Enantioselective C(sp²)–H Borylation for the Synthesis of Axially Chiral Biaryls

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

We report an ether-directed enantioselective C(sp2)-H borylation catalyzed by a chiral bidentate boryl ligand (CBL)/iridium system for constructing axially biaryls. This method delivered diverse biaryls with good to high enantioselectivities, accommodating varied electronic and steric substituents on the aryl rings. Gram-scale synthesis downstream transformations of C-B bond underscored its practicality.

Language: Английский

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Oxidative Alkenylation of (Hetero)aromatics with Unactivated Alkenes: Control of the Reaction Selectivity

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(9), P. 1922 - 1949

Published: Feb. 23, 2024

Abstract Alkenylbenzene skeletons represent one of the most widely occurring structural motifs in pharmaceutical drugs, natural products, and advanced materials. The construction alkenylbenzenes is promising through use a straightforward oxidative alkenylation protocol, particularly from unactivated alkenes. This significant because alkenes are inexpensive raw materials that can be obtained bulk quantities petrochemical feedstocks renewable resources. However, controlling reactivity regioselectivity olefination with unbiased olefins remains challenge, necessitating continuous efforts potentially having substantial impact on both organic synthesis industry. review aims to provide an overview latest advances regiocontrol strategies for reactions alkenes, which categorized into three types: 1) ligand‐promoted/accelerated reactions; 2) prefunctionalized olefins‐facilitated 3) directing group‐induced reactions.

Language: Английский

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Palladium-Catalyzed Ligand-Enabled Cyclization of Substituted Aliphatic Carboxylic Acids with Allylic Electrophiles

Organic Letters, Journal Year: 2024, Volume and Issue: 26(31), P. 6580 - 6585

Published: July 25, 2024

A palladium-catalyzed cyclization of the β-C(sp

Language: Английский

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Asymmetric 1,2-diaxial synthesis of bi-(hetero)aryl benzofulvene atropisomers via transient directing group-assisted dehydrogenative coupling

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(18), P. 2524 - 2527

Published: Jan. 1, 2024

The efficient cross-dehydrogenative coupling of electronically rich and sterically congested benzofulvene with bi-(hetero)aryl moieties to construct an axially chiral core remains a formidable task.

Language: Английский

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