P-Stereogenic Phosphorus Ligands in Asymmetric Catalysis

Chemical Reviews, Год журнала: 2024, Номер 124(14), С. 8657 - 8739

Опубликована: Июль 2, 2024

Chiral phosphorus ligands play a crucial role in asymmetric catalysis for the efficient synthesis of useful optically active compounds. They are largely categorized into two classes: backbone chirality and P-stereogenic ligands. Most reported belong to former class. Privileged ones such as BINAP DuPhos frequently employed wide range catalytic transformations. In contrast, latter class has remained small family many years mainly because their synthetic difficulty. The late 1990s saw emergence novel with superior enantioinduction ability Rh-catalyzed hydrogenation reactions. Since then, numerous have been synthesized used This Review summarizes thus far, including stereochemical electronic properties that afford high excellent enantioselectivities. Examples reactions use this described together applications construction key intermediates natural products therapeutic agents. literature covered dates back 1968 up until December 2023, centering on studies published later years.

Язык: Английский

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Enantioselective synthesis of molecules with multiple stereogenic elements

Chemical Society Reviews, Год журнала: 2024, Номер 53(22), С. 11165 - 11206

Опубликована: Янв. 1, 2024

This review explores the fascinating world of molecules featuring multiple stereogenic elements, unraveling different strategies designed over years for their enantioselective synthesis.

Язык: Английский

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Development of Configurationally Labile Biaryl Reagents for Atropisomer Synthesis

European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(28)

Опубликована: Май 16, 2024

Abstract Axially chiral biaryl scaffolds are important in pharmaceuticals, natural products, and asymmetric synthesis. Atroposelective ring‐opening of configurationally labile reagents via dynamic kinetic transformation provides a valuable approach to access axially atropisomers. This review summarizes seminal contributions recent advancements on this topic based the use different types reagents.

Язык: Английский

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Pd-catalyzed enantioselective and regioselective asymmetric hydrophosphorylation and hydrophosphinylation of enynes

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110231 - 110231

Опубликована: Июль 1, 2024

Язык: Английский

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Modular Assembly of Axially Chiral QUINAP Derivatives via Nickel-Catalyzed Enantioselective C–P Cross-Coupling

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 8268 - 8273

Опубликована: Май 2, 2025

Язык: Английский

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Catalytic construction of P-stereogenic center via phosphorus-centered nucleophilic substitution

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111052 - 111052

Опубликована: Март 1, 2025

Язык: Английский

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Recent advances in the catalytic asymmetric construction of axially chiral azole-based frameworks

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(23), С. 6819 - 6849

Опубликована: Янв. 1, 2024

This review highlights recent advances in the atroposelective preparation of axially chiral azole derivatives, emphasizing mechanistic insights and synthetic applications development this class five-membered heterocyclic frameworks.

Язык: Английский

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NiII, PdII and PtII pincer complexes of 2-(diphenylphosphaneyl)-N-(2-(diphenyl-phosphaneyl)benzyl)benzamide: synthesis, reactivity and catalytic studies

Dalton Transactions, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This paper describes the synthesis of bis(phosphine), o -Ph 2 PC 6 H 4 C(O)N(H)CH C PPh - and its group 10 metal chemistry catalytic studies.

Язык: Английский

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Dithiophosphinylation of Allenyl Acetates: Access to 1,2-Bis(diphenylphosphino)ethane-Type Bidentate Ligands

Organic Letters, Год журнала: 2024, Номер 26(16), С. 3453 - 3457

Опубликована: Апрель 11, 2024

1,2-Bis(diphenylphosphino)ethanes (DPPEs) are versatile and immensely important ligands in transition metal catalysts. Here we report the dithiophosphinylation of readily available allenyl acetates to give DPPEs high yields regioselectivity. This protocol features a broad substrate scope mild conditions, avoiding use metals air-sensitive sources phosphorus. Mechanism studies indicate that reaction was accomplished via an SN2′-type addition–elimination followed by 1,4-addition step.

Язык: Английский

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A Review on Functionalization of Benzo‐5,6‐Fused Bicyclic Heteroaromatic Compounds

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(22)

Опубликована: Июль 16, 2024

Abstract Over the decades, functionalized heteroaromatic compounds and their scaffolds have drawn significant attention in synthetic organic chemistry as well interdisciplinary sciences due to prevalence natural products, hormones, vitamins, applications pharmaceuticals, agrochemicals, veterinary dyes pigments, bio‐imaging, semiconductors, optoelectronics, etc. This review explores various strategies for functionalization of numerous 5,6 benzo‐fused derivatives such indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, benzothiazole benzotriazole through methods including C−H activation, cross‐coupling, metal catalysis, photo‐catalysis, electrocatalysis organocatalysis recent years (2019–2023). Highly heterocyclic are important precursors synthesizing many bioactive drugs like fenbendazole, viozan, griseofulvin, zileuton, flunoxaprofen, optoelectronic materials,

Язык: Английский

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