Abstract
Quinazolines,
particularly
fluoro-quinazolines,
represent
important
structural
motifs
in
bioactive
molecules
and
pharmaceuticals.
Despite
several
known
synthetic
routes,
the
efficient
synthesis
of
fluorine-containing
quinazolines
remains
a
challenge.
Herein,
straightforward
sustainable
fluorine-substituted
using
domino
sequences
is
reported.
The
obtained
novel
fluoro-quinazoline
compounds
exhibit
significant
vitro
activity
against
human
cytomegalovirus
(HCMV),
expanding
library
potential
antiviral
drug
compounds.
Our
finding
outlays
toolkit
for
fluoro-quinazolines
introduces
new
agents
HCMV
therapy.
Chemical Communications,
Год журнала:
2024,
Номер
60(69), С. 9254 - 9257
Опубликована: Янв. 1, 2024
We
report
the
utilisation
of
an
iodine(
iii
)
reagent
to
access
α,β-unsaturated
carbonyls
from
corresponding
silyl
enol
ethers
and
phosphates.
The
transformation
can
also
be
carried
out
in
one
pot,
directly
dehydrogenating
carbonyls.
Abstract
Quinazolines,
particularly
fluoro-quinazolines,
represent
important
structural
motifs
in
bioactive
molecules
and
pharmaceuticals.
Despite
several
known
synthetic
routes,
the
efficient
synthesis
of
fluorine-containing
quinazolines
remains
a
challenge.
Herein,
straightforward
sustainable
fluorine-substituted
using
domino
sequences
is
reported.
The
obtained
novel
fluoro-quinazoline
compounds
exhibit
significant
vitro
activity
against
human
cytomegalovirus
(HCMV),
expanding
library
potential
antiviral
drug
compounds.
Our
finding
outlays
toolkit
for
fluoro-quinazolines
introduces
new
agents
HCMV
therapy.
