Facile Synthesis of New Antiviral Fluoro-Quinazolines Enabled by Merging Domino Reactions DOI
Svetlana B. Tsogoeva,

Sascha Kohlbauer,

Honglin Xia

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Quinazolines, particularly fluoro-quinazolines, represent important structural motifs in bioactive molecules and pharmaceuticals. Despite several known synthetic routes, the efficient synthesis of fluorine-containing quinazolines remains a challenge. Herein, straightforward sustainable fluorine-substituted using domino sequences is reported. The obtained novel fluoro-quinazoline compounds exhibit significant vitro activity against human cytomegalovirus (HCMV), expanding library potential antiviral drug compounds. Our finding outlays toolkit for fluoro-quinazolines introduces new agents HCMV therapy.

Language: Английский

Versatile dehydrogenation of carbonyls enabled by an iodine(iii) reagent DOI Creative Commons
Bence B. Botlik, Patrick Finkelstein, Ann-Sophie K. Paschke

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(69), P. 9254 - 9257

Published: Jan. 1, 2024

We report the utilisation of an iodine( iii ) reagent to access α,β-unsaturated carbonyls from corresponding silyl enol ethers and phosphates. The transformation can also be carried out in one pot, directly dehydrogenating carbonyls.

Language: Английский

Citations

0
Six-membered ring systems: Diazines and benzo derivatives DOI

K. Alison Rinderspacher

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393

Published: Jan. 1, 2024

Citations

0
Five-membered ring systems: Pyrroles and benzo analogs DOI
Chuan Shan, Justin M. Lopchuk

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 173

Published: Jan. 1, 2024

Language: Английский

Citations

0
Facile Synthesis of New Antiviral Fluoro-Quinazolines Enabled by Merging Domino Reactions DOI
Svetlana B. Tsogoeva,

Sascha Kohlbauer,

Honglin Xia

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Quinazolines, particularly fluoro-quinazolines, represent important structural motifs in bioactive molecules and pharmaceuticals. Despite several known synthetic routes, the efficient synthesis of fluorine-containing quinazolines remains a challenge. Herein, straightforward sustainable fluorine-substituted using domino sequences is reported. The obtained novel fluoro-quinazoline compounds exhibit significant vitro activity against human cytomegalovirus (HCMV), expanding library potential antiviral drug compounds. Our finding outlays toolkit for fluoro-quinazolines introduces new agents HCMV therapy.

Language: Английский

Citations

0