Visible-light-induced dehydrogenation of dihydroquinolinones via the combination of energy transfer and hydrogen atom transfers DOI
Feng Jin, Huayang Tang, Hao Guo

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

A visible-light-induced dehydrogenation of dihydroquinolinones was developed using photocatalyst thioxanthone (TX) and oxidant tert -butyl benzoperoxoate.

Язык: Английский

A Domino Dearomative ipso-Annulation/Desymmetrization Approach: Stereoselective Access to Tricyclic Alkaloid Skeletons DOI
Chada Raji Reddy,

A. Prasad,

Uprety Ajaykumar

и другие.

Organic Letters, Год журнала: 2024, Номер 26(23), С. 4904 - 4909

Опубликована: Июнь 5, 2024

Herein, we reveal an unprecedented domino annulation of

Язык: Английский

Процитировано

9

Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone DOI
Shiqiang Wei, Zihao Li, Shuanghu Wang

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(28), С. 18841 - 18847

Опубликована: Июль 8, 2024

An asymmetric intramolecular spiro-amination to high steric hindering

Язык: Английский

Процитировано

5

Recent Developments for the Catalytic Asymmetric Synthesis of Indolin-3-one Derivatives DOI

Atul Jankiram Dolas,

Arun L. Patel,

Imtiyaz Ahmad Shah

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

2,2-Disubstituted indolin-3-ones, which are essential components in many manufactured chemicals, dyes, and naturally occurring bioactive alkaloids, have emerged as exciting synthetic targets. Much attention has been paid to accessing these units, particularly an asymmetric fashion, during the last decade. In this review article, we discuss current state of available methods with existing mechanistic pathways for chiral indolin-3-one derivatives under various catalytic systems. This overall presentation protocols access 2,2-disubstituted or fused indolin-3-ones aza-quaternary centre is categorized based on reaction modes 2-substituted-3H-indole-3-one other similar protocols.

Язык: Английский

Процитировано

0

Synthesis of C2-Spiroindolines Based on the Cascade Reaction of 2-Aryl-3H-indoles with Cyclopropanols DOI

Xueying Yang,

Yuanshuang Xu, Xinying Zhang

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 694 - 694

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Access to Methylidene-Azaspiro[4.5]decatrienones via Radical-Promoted Domino Thio-Functionalization/Dearomative Ipso-Annulation DOI
Chada Raji Reddy,

Puthiya Purayil Vinaya,

Ejjirotu Srinivasu

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

An unprecedented approach involving radical-mediated sulfonylation/dearomative ipso-annulation of N-(methyl-2-phenylacetate)propiolamides using arylsulfonyl radical, generated from aryl diazonium salt in the presence DABSO, is developed. This strategy provides uniquely substituted 3-sulfonyl azaspiro[4.5]decatrienones good yields. The developed has also been extended fruitfully to 3-thiocyano aza-spirocycles through domino thiocyanation/dearomative ipso-annulation.

Язык: Английский

Процитировано

0

Electrochemical selenylative ipso-Annulation of N-benzylacrylamides to seleno-azaspiro[4.5]decadienones DOI
Chada Raji Reddy,

Jannatul Islam,

Thallamapuram Nagendraprasad

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(30), С. 6141 - 6148

Опубликована: Янв. 1, 2024

Construction of seleno azaspiro[4.5]decadienones using an electrochemical approach is achieved via domino selenylation/ ipso -annulation.

Язык: Английский

Процитировано

2

Ag-Catalyzed Domino Decarboxylative Alkylation/Dearomative Annulation: Entry to Fused-Pyrido[4,3-b]Indolones DOI
Chada Raji Reddy,

Ejjirotu Srinivasu,

Agnuru Theja

и другие.

Organic Letters, Год журнала: 2024, Номер 26(42), С. 9146 - 9150

Опубликована: Окт. 10, 2024

Here we report the development of unprecedented silver-catalyzed intramolecular annulations

Язык: Английский

Процитировано

1

Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities DOI Creative Commons
Prakash T. Parvatkar,

Khaly Diagne,

Yingzhao Zhao

и другие.

ChemMedChem, Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Abstract Malaria infections affect almost half of the world‘s population, with over 200 million cases reported annually. Cryptolepis sanguinolenta , a plant native to West Africa, has long been used across various regions Africa for malaria treatment. Chemical analysis revealed that is abundant in indoloquinolines, which have shown possess antimalarial properties. Cryptolepine, neocryptolepine, and isocryptolepine are well‐studied indoloquinoline alkaloids known their potent activity. However, structural rigidity associated cellular toxicity major drawbacks preclinical development. This review focuses on potential (cryptolepine, isocryptolepine) as scaffolds drug discovery. The article delves into effects vitro vivo, well proposed mechanisms action structure‐activity relationship studies. Several studies aim improve these leads by reducing cytotoxicity while preserving or enhancing activity gaining insights action. These investigations highlight indoloquinolines scaffold developing new drugs.

Язык: Английский

Процитировано

0

Electrochemical domino sulfonylation/dearomative ipso‐annulation of 2‐alkynyl biaryls to access spiro(indenyl)cyclohexadienones DOI
Chada Raji Reddy,

Karna Nair,

Puthiya Purayil Vinaya

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 2, 2024

Abstract Herein, we present an efficient strategy for the synthesis of spiro(indenyl)cyclohexadienones through radical‐promoted reaction 2‐alkynyl biaryls with sodium sulfinates under electrochemical conditions. The involves sulfonylation and dearomative ipso‐ cyclisation in a domino fashion. This approach features use readily accessible precursors, wide functional group tolerance external oxidant‐free practicality method was also illustrated by scale‐up further diversification product.

Язык: Английский

Процитировано

0

Visible-light-induced dehydrogenation of dihydroquinolinones via the combination of energy transfer and hydrogen atom transfers DOI
Feng Jin, Huayang Tang, Hao Guo

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

A visible-light-induced dehydrogenation of dihydroquinolinones was developed using photocatalyst thioxanthone (TX) and oxidant tert -butyl benzoperoxoate.

Язык: Английский

Процитировано

0