Visible-light-induced dehydrogenation of dihydroquinolinones via the combination of energy transfer and hydrogen atom transfers DOI
Feng Jin, Huayang Tang, Hao Guo

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

A visible-light-induced dehydrogenation of dihydroquinolinones was developed using photocatalyst thioxanthone (TX) and oxidant tert -butyl benzoperoxoate.

Language: Английский

A Domino Dearomative ipso-Annulation/Desymmetrization Approach: Stereoselective Access to Tricyclic Alkaloid Skeletons DOI
Chada Raji Reddy,

A. Prasad,

Uprety Ajaykumar

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(23), P. 4904 - 4909

Published: June 5, 2024

Herein, we reveal an unprecedented domino annulation of

Language: Английский

Citations

9
Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone DOI
Shiqiang Wei, Zihao Li, Shuanghu Wang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(28), P. 18841 - 18847

Published: July 8, 2024

An asymmetric intramolecular spiro-amination to high steric hindering

Language: Английский

Citations

5
Recent Developments for the Catalytic Asymmetric Synthesis of Indolin-3-one Derivatives DOI

Atul Jankiram Dolas,

Arun L. Patel,

Imtiyaz Ahmad Shah

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

2,2-Disubstituted indolin-3-ones, which are essential components in many manufactured chemicals, dyes, and naturally occurring bioactive alkaloids, have emerged as exciting synthetic targets. Much attention has been paid to accessing these units, particularly an asymmetric fashion, during the last decade. In this review article, we discuss current state of available methods with existing mechanistic pathways for chiral indolin-3-one derivatives under various catalytic systems. This overall presentation protocols access 2,2-disubstituted or fused indolin-3-ones aza-quaternary centre is categorized based on reaction modes 2-substituted-3H-indole-3-one other similar protocols.

Language: Английский

Citations

0
Synthesis of C2-Spiroindolines Based on the Cascade Reaction of 2-Aryl-3H-indoles with Cyclopropanols DOI

Xueying Yang,

Yuanshuang Xu, Xinying Zhang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(2), P. 694 - 694

Published: Jan. 1, 2025

Language: Английский

Citations

0
Access to Methylidene-Azaspiro[4.5]decatrienones via Radical-Promoted Domino Thio-Functionalization/Dearomative Ipso-Annulation DOI
Chada Raji Reddy,

Puthiya Purayil Vinaya,

Ejjirotu Srinivasu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

An unprecedented approach involving radical-mediated sulfonylation/dearomative ipso-annulation of N-(methyl-2-phenylacetate)propiolamides using arylsulfonyl radical, generated from aryl diazonium salt in the presence DABSO, is developed. This strategy provides uniquely substituted 3-sulfonyl azaspiro[4.5]decatrienones good yields. The developed has also been extended fruitfully to 3-thiocyano aza-spirocycles through domino thiocyanation/dearomative ipso-annulation.

Language: Английский

Citations

0
Electrochemical selenylative ipso-Annulation of N-benzylacrylamides to seleno-azaspiro[4.5]decadienones DOI
Chada Raji Reddy,

Jannatul Islam,

Thallamapuram Nagendraprasad

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(30), P. 6141 - 6148

Published: Jan. 1, 2024

Construction of seleno azaspiro[4.5]decadienones using an electrochemical approach is achieved via domino selenylation/ ipso -annulation.

Language: Английский

Citations

2
Ag-Catalyzed Domino Decarboxylative Alkylation/Dearomative Annulation: Entry to Fused-Pyrido[4,3-b]Indolones DOI
Chada Raji Reddy,

Ejjirotu Srinivasu,

Agnuru Theja

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9146 - 9150

Published: Oct. 10, 2024

Here we report the development of unprecedented silver-catalyzed intramolecular annulations

Language: Английский

Citations

1
Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities DOI Creative Commons
Prakash T. Parvatkar,

Khaly Diagne,

Yingzhao Zhao

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Malaria infections affect almost half of the world‘s population, with over 200 million cases reported annually. Cryptolepis sanguinolenta , a plant native to West Africa, has long been used across various regions Africa for malaria treatment. Chemical analysis revealed that is abundant in indoloquinolines, which have shown possess antimalarial properties. Cryptolepine, neocryptolepine, and isocryptolepine are well‐studied indoloquinoline alkaloids known their potent activity. However, structural rigidity associated cellular toxicity major drawbacks preclinical development. This review focuses on potential (cryptolepine, isocryptolepine) as scaffolds drug discovery. The article delves into effects vitro vivo, well proposed mechanisms action structure‐activity relationship studies. Several studies aim improve these leads by reducing cytotoxicity while preserving or enhancing activity gaining insights action. These investigations highlight indoloquinolines scaffold developing new drugs.

Language: Английский

Citations

0
Electrochemical domino sulfonylation/dearomative ipso‐annulation of 2‐alkynyl biaryls to access spiro(indenyl)cyclohexadienones DOI
Chada Raji Reddy,

Karna Nair,

Puthiya Purayil Vinaya

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Herein, we present an efficient strategy for the synthesis of spiro(indenyl)cyclohexadienones through radical‐promoted reaction 2‐alkynyl biaryls with sodium sulfinates under electrochemical conditions. The involves sulfonylation and dearomative ipso‐ cyclisation in a domino fashion. This approach features use readily accessible precursors, wide functional group tolerance external oxidant‐free practicality method was also illustrated by scale‐up further diversification product.

Language: Английский

Citations

0
Visible-light-induced dehydrogenation of dihydroquinolinones via the combination of energy transfer and hydrogen atom transfers DOI
Feng Jin, Huayang Tang, Hao Guo

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

A visible-light-induced dehydrogenation of dihydroquinolinones was developed using photocatalyst thioxanthone (TX) and oxidant tert -butyl benzoperoxoate.

Language: Английский

Citations

0