Dalton Transactions,
Год журнала:
2024,
Номер
54(3), С. 1212 - 1221
Опубликована: Ноя. 18, 2024
A
complex
of
earth-abundant
chromium
mediates
C–C
and
C–N
bond
formation
via
alcohol
dehydrogenation,
forming
C
-alkylated
ketones
secondary
alcohols,
as
well
quinoline
synthesis
by
a
modified
Friedländer
reaction.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
streamlined
strategy
for
the
one-pot
synthesis
of
isoxazolone
analogues
has
been
developed
through
an
acceptorless
dehydrogenative
annulation
(ADA)
pathway
by
employing
new
Ru(II)
hydride
complexes
as
effective
catalysts.
New
(C1–C3)
tailored
with
N̂O
chelating
carbazolone
benzhydrazone
ligands
were
synthesized
and
their
formation
was
confirmed
using
analytical
spectral
techniques
including
FT-IR
NMR.
The
structural
configuration
featuring
octahedral
geometry
around
ion
precisely
determined
single-crystal
X-ray
diffraction
analysis.
Further,
catalytic
efficacy
titled
established
facile
productive
derivatives
from
a
diverse
range
benzyl
alcohols,
methyl
acetoacetate/ethyl
benzoylacetate
hydroxylamine
hydrochloride,
generating
excellent
yields
up
to
93%
under
well-suited
mild
conditions
1
mol
%
catalyst
loading.
sequence
time-dependent
control
experiments
unveiled
ADA
route,
indicating
initial
generation
4-methoxy
benzaldehyde
intermediate
followed
3-phenylisoxazol-5(4H)-one,
accompanied
release
water
hydrogen
byproducts.
Gram-scale
compound
indicates
industrial
relevance
our
synthetic
strategy.
short
medicinally
active
androgen
antagonist
illustrates
utility
present
protocol.
Abstract
Recently,
quinoline
has
emerged
as
a
critical
heterocyclic
structure,
attracting
attention
for
its
diverse
industrial
and
synthetic
organic
chemistry
applications.
This
compound
is
essential
developing
novel
lead
compounds
in
drug
discovery
extensively
studied
therapeutic
derivatives
medicinal
chemistry.
An
extensive
body
of
literature
details
the
methodologies
synthesizing
this
key
scaffold
functionalization
to
enhance
biological
efficacy.
Numerous
synthesis
protocols
have
been
documented,
highlighting
significance
ongoing
chemical
research.
These
include
various
strategies,
such
transition
metal‐catalyzed
reactions
environmentally
sustainable
processes,
which
are
crucial
constructing
functionalizing
derivatives.
review
aims
systematically
examine
procedures
findings,
addressing
limitations
these
pathways
their
environmental
impacts.
Additionally,
curated
selection
quinolines
will
be
presented.
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 5, 2025
The
convenient
and
effective
catalytic
synthesis
of
quinazolines
holds
considerable
significance
due
to
their
high
economic
value,
designing
a
cluster-type
alkali-resisting
catalyst
such
as
polyoxometalates
(POMs)
still
poses
significant
challenge.
Herein,
three
lanthanum
ion-doped
steady
polyoxophosphitemolybdates
with
the
formulas
[CH3NH3]6{La(H2O)3Na[Mo6O12(OH)3(HPO3)4]2}·10H2O
(1),
[CH3NH3]2{La(H2O)[Mo6O12(OH)3(HPO3)4]}·8H2O
(2),
[CH3NH3]5{La2(H2O)8Na[Mo6O12(OH)3(HPO3)3
(PO4)]2}·16H2O
(3)
were
synthesized
by
using
HPO32-
template.
Structural
analysis
revealed
that
1
forms
three-dimensional
structure
through
connection
La3+
an
hourglass-shaped
{Na[P4Mo6O27]2}
unit.
2
porous
channel
same
{P4Mo6O27}
building
block.
When
synthetic
microenvironment
was
adjusted
changing
type
reducing
agent,
some
hypophosphite
in
units
oxidized,
thereby
altering
structure,
compound
3
formed.
All
compounds
are
alkali-resistant
catalytically
active
toward
conversion
2-aminobenzyl
alcohol
benzonitrile
into
2-phenylquinazoline,
achieves
best
yield
91.7%,
which
is
much
better
than
those
classic
Keggin
{PMo12}
inorganic
CaMoO4,
indicating
synergistic
effect
Mo
La
centers.
Also,
exhibits
good
activity
reliability
catalyzing
reactions
different
substrates.
Catalysis Science & Technology,
Год журнала:
2024,
Номер
14(20), С. 5959 - 5969
Опубликована: Янв. 1, 2024
This
manuscript
describes
the
synthesis
of
triazolyl-pyridine-based
pincer
cationic
and
neutral
nickel
complexes
their
application
in
microwave-assisted
quinolines.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
In
this
report,
a
new
imidazole-
and
amide-functionalized
pincer-like
Cu(II)
complex
(1)
was
synthesized
characterized.
By
employing
1
9-azabicyclo[3.3.1]nonane
NH-Oxyl
(ABNOH),
catalytic
protocol
for
alcohol
oxidation
the
subsequent
oxidation-triggered
synthesis
of
quinolines
pyrazines
were
explored.
Alcohols
such
as
2-aminoaryl
alcohols
also
oxidized
efficiently.
As
carbonyls
from
2-arylaminobenzyl
secondary
are
synthons
quinolines,
we
explored
their
directly
alcohols.
The
quite
efficient
completed
reaction
in
only
∼5–10
h.
Combinations
(a)
primary
with
or
ketones
(b)
found
to
be
very
effective
quinolines.
successful
various
1,2-diols
1,2-diaminobenzenes
10
Mechanistic
investigations
showed
that
generated
acted
an
active
catalyst:
it
activated
O2
subsequently
cooperation
N-Oxyl
(ABNO•)
α-CH
hydrogen
coordinated
alkoxide.
Then,
Cu(II)/Cu(I)
reduction
led
formation
carbonyl
compounds,
which
via
successive
C–C/C–N
coupling
reactions
resulted
heterocycles
presence
KOtBu
1.
Organic Process Research & Development,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 7, 2024
As
the
field
of
nonprecious
metal
catalysis
continues
to
expand,
we
pursue
a
review
series
covering
selected
transformations
in
this
area
over
short
time
interval
highlight
practical
advancements.
We
seek
raise
awareness
both
current
art
and
need
continue
development
toward
broader
applications
earth-abundant
metals
chemical
pharmaceutical
industries.