European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
This
work
reports
a
Cu‐catalyzed
coupling
technique
for
synthesizing
(
E
)‐dienyl
sulfones
and
β‐chlorosulfones
from
1‐arylbutadienes
styrenes,
respectively.
By
employing
easily
available
inexpensive
reagents,
this
method
enables
the
synthesis
of
diverse
array
dienyl
with
excellent
functional
group
tolerance
under
base‐
oxidant‐free
conditions.
It
also
proves
versatile
late‐stage
functionalization
drug
molecules
scale‐up
reactions.
The
showcases
notable
selectivity,
gentle
reaction
conditions,
compatibility
various
groups
as
demonstrated
through
66
examples
display
regioselectivity.
A
successful
methodology
for
the
copper-catalyzed
dehydrogenated
methylsulfonylation
of
alkenes
utilizing
CH3SSO3Na
in
conjunction
with
hypervalent
iodine
reagents
was
successfully
established.
This
method
offers
a
practical
avenue
to
obtain
allyl
methyl
sulfones
and
alkenyl
by
forming
C-S
bonds.
Using
C-H
bond
oxidation
sulfonylation
strategy
Bunte
salts,
we
synthesized
total
twenty
two
compounds,
including
four
examples
deuterium-substituted
molecules,
demonstrated
one
example
scale-up
reaction.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
radical-mediated
sulfonylation
relay
of
alkyl
alkynes/alkenes
with
electron-deficient
alkenes
using
Na
2
S
O
4
as
a
linker
is
developed
to
synthesize
highly
selective
(
Z
)-vinyl
and
sulfones
under
metal-free
catalyzed
system.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
An
environmentally
friendly
and
practical
method
for
the
synthesis
of
various
vinyl
sulfones
was
developed
through
direct
sulfonylation
alkenyl
sulfonium
salts
with
sulfinic
acids.
The
reaction
effectively
triggered
by
combined
actions
milling,
sunlight,
photocatalysts
under
solvent-free
conditions,
offering
advantages
such
as
a
short
time
(5-10
min),
room
temperature,
straightforward
workup
procedure.
Preliminary
mechanistic
studies
suggested
that
sulfonyl
radical
may
be
involved
in
this
mechanophotocatalytic
transformation
process.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Herein,
we
described
the
addition
reactions
of
sulfur-containing
reagents
(sodium
sulfinates,
dithiosulfonates)
with
α-trifluoromethyl
alkenes
under
visible
light.
A
series
trifluoromethyl
sulfonates
were
synthesized
via
visible-light-induced
radical
reaction
sodium
sulfinates
and
to
obtain
protons
from
solvent.
dithiosulfonated
derivatives
bifunctionalization
dithiosulfonates.This
strategy
has
advantages
mild
conditions,
good
substrate
universality
high
yield
up
99%
yield.
Zeitschrift für Kristallographie - New Crystal Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
Abstract
C
24
H
16
F
2
N
O
4
Cu,
triclinic,
P1‾
$P\overline{1}$
(no.
2),
a
=
5.3203(6)
Å,
b
9.0861(11)
c
11.5282(10)
α
103.718(9)°,
β
97.964(9)°,
γ
98.771(10)°,
V
526.12(10)
Å
3
,
Z
1,
R
gt
(
)
0.0497,
wR
ref
0.1000,
T
298
K.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(12), С. 3320 - 3325
Опубликована: Янв. 1, 2024
A
practical
method
for
the
cross-coupling
of
ethyl
3-bromo-3-alkyl-2,2-difluoropropanoates
with
coumarins/quinolinones
was
developed.
The
IC
50
values
3l
against
Huh-7
and
A549
cells
were
determined
to
be
4.6
μM
6.8
μM,
respectively.
Organic Letters,
Год журнала:
2024,
Номер
26(27), С. 5799 - 5804
Опубликована: Июль 2, 2024
Herein,
we
disclose
a
photoinduced
radical
cascade
cyclization
of
alkynes
with
sulfinates
via
novel
EDA
complex
for
the
synthesis
various
3-sulfonylindoles
and
vinyl
sulfone
oxindoles,
which
are
crucial
motifs
in
medicinal
biological
chemistry.
The
reaction
proceeds
under
mild,
photocatalyst-
transition-metal-free
conditions,
featuring
operational
simplicity,
broad
substrate
scope,
easy
scalability.
Mechanistic
studies
reveal
that
is
initiated
intermolecular
charge
transfer
from
to
N-sulfonamides,
generating
sulfonyl
followed
by
an
N-centered
radical,
thus
enabling
process.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10919 - 10928
Опубликована: Июль 16, 2024
An
efficient
visible-light-induced
synthesis
of
vinyl
sulfones
has
been
accomplished
via
decarboxylative
sulfonylation
cinnamic
acids
using
sulfonylazides,
Chemical Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
new
photochemical
method
to
prepare
alkenyl
thioethers
under
both
batch
and
continuous
flow
conditions
is
presented.
These
versatile
building
blocks
enable
the
synthesis
of
various
organosulfur
compounds,
highlighting
utility
this
procedure.
