Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A new photochemical method to prepare alkenyl thioethers under both batch and continuous flow conditions is presented. These versatile building blocks enable the synthesis of various organosulfur compounds, highlighting utility this procedure.
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10660 - 10677
Published: July 18, 2024
Two general protocols for the regioselective electrochemically enabled sulfonylation cyclization of
Language: Английский
Citations
8
BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)
Published: Feb. 22, 2025
A successful methodology for the copper-catalyzed dehydrogenated methylsulfonylation of alkenes utilizing CH3SSO3Na in conjunction with hypervalent iodine reagents was successfully established. This method offers a practical avenue to obtain allyl methyl sulfones and alkenyl by forming C-S bonds. Using C-H bond oxidation sulfonylation strategy Bunte salts, we synthesized total twenty two compounds, including four examples deuterium-substituted molecules, demonstrated one example scale-up reaction.
Language: Английский
Citations
0
Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A radical-mediated sulfonylation relay of alkyl alkynes/alkenes with electron-deficient alkenes using Na 2 S O 4 as a linker is developed to synthesize highly selective ( Z )-vinyl and sulfones under metal-free catalyzed system.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
An environmentally friendly and practical method for the synthesis of various vinyl sulfones was developed through direct sulfonylation alkenyl sulfonium salts with sulfinic acids. The reaction effectively triggered by combined actions milling, sunlight, photocatalysts under solvent-free conditions, offering advantages such as a short time (5-10 min), room temperature, straightforward workup procedure. Preliminary mechanistic studies suggested that sulfonyl radical may be involved in this mechanophotocatalytic transformation process.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Herein, we described the addition reactions of sulfur-containing reagents (sodium sulfinates, dithiosulfonates) with α-trifluoromethyl alkenes under visible light. A series trifluoromethyl sulfonates were synthesized via visible-light-induced radical reaction sodium sulfinates and to obtain protons from solvent. dithiosulfonated derivatives bifunctionalization dithiosulfonates.This strategy has advantages mild conditions, good substrate universality high yield up 99% yield.
Language: Английский
Citations
0
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(12), P. 3320 - 3325
Published: Jan. 1, 2024
A practical method for the cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones was developed. The IC 50 values 3l against Huh-7 and A549 cells were determined to be 4.6 μM 6.8 μM, respectively.
Language: Английский
Citations
3
Organic Letters, Journal Year: 2024, Volume and Issue: 26(27), P. 5799 - 5804
Published: July 2, 2024
Herein, we disclose a photoinduced radical cascade cyclization of alkynes with sulfinates via novel EDA complex for the synthesis various 3-sulfonylindoles and vinyl sulfone oxindoles, which are crucial motifs in medicinal biological chemistry. The reaction proceeds under mild, photocatalyst- transition-metal-free conditions, featuring operational simplicity, broad substrate scope, easy scalability. Mechanistic studies reveal that is initiated intermolecular charge transfer from to N-sulfonamides, generating sulfonyl followed by an N-centered radical, thus enabling process.
Language: Английский
Citations
1
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10919 - 10928
Published: July 16, 2024
An efficient visible-light-induced synthesis of vinyl sulfones has been accomplished via decarboxylative sulfonylation cinnamic acids using sulfonylazides,
Language: Английский
Citations
1
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 31(8)
Published: Nov. 22, 2024
Vinyl sulfones are valued for their unique chemical properties and bioactivity, but creating a wide range of different analogs remains challenge. To address this limitation, we have developed novel approach that facilitates the synthesis polysubstituted vinyl sulfones. This method utilizes dual functionality NIS as promoter enables sulfonation elimination in We used broad applicability, efficiency, selectivity, functional group tolerance to synthesize more than 70 examples. Additionally, competition experiments provided insights into reactivity selectivity transient sulfonyl radical towards various C-C multiple bonds. Herein, describe using mild protocol late-stage complex molecules simplify specific targets enable modification natural products advanced materials.
Language: Английский
Citations
1
Synlett, Journal Year: 2024, Volume and Issue: unknown
Published: June 15, 2024
Abstract We report a useful flow protocol for the preparation of alkenyl thioethers from bromides and thiols in basic media with visible-light irradiation. The reactions exhibit wide functional-group tolerance, proceed under mild conditions, are stereoselective, do not require use catalysts. transformations can be successfully scaled up to 5 mmol scale without compromising yield. key success these is photochemical excitation halogen-bonding complexes form sulfur-centered radicals, recently developed our laboratories.
Language: Английский
Citations
0