Molecules,
Год журнала:
2024,
Номер
30(1), С. 102 - 102
Опубликована: Дек. 30, 2024
tert-Butyl
hypochlorite
was
employed
as
a
versatile
reagent
for
chlorooxidation
of
indoles,
chlorination
2-oxindoles,
and
decarboxylative
the
indole-2-carboxylic
acids.
Four
types
products
including
2-chloro-3-oxindoles,
2,2-dichloro-3-oxindoles,
3,3-dichloro-2-oxindoles,
2,3-dichloroindoles
could
be
selectively
obtained
in
moderate
to
excellent
yields
by
switching
substrates.
Various
synthetically
useful
functional
groups,
such
halogen
atoms,
cyano,
nitro,
methoxycarbonyl
remain
intact
during
reactions.
Notable
features
approach
include
universality
starting
materials,
mild
reaction
conditions,
experimental
simplicity.
Molecules,
Год журнала:
2024,
Номер
29(17), С. 4241 - 4241
Опубликована: Сен. 6, 2024
Xanthones
are
chemical
substances
in
higher
plants,
marine
organisms,
and
lower
microorganisms.
The
most
prevalent
naturally
occurring
sources
of
xanthones
those
belonging
to
the
families
Caryophyllaceae,
Guttiferae,
Gentianaceae.
Structurally,
(9H
xanthan-9-one)
heterocyclic
compounds
with
oxygen
a
γ-pyrone
component.
They
densely
packed
two-benzene
ring
structure.
carbons
numbered
from
their
nucleus
biosynthetic
construct.
have
mixed
shikimate-acetate
(higher
plants)
acetate-malonate
(lower
organisms)
origins,
which
influence
classification.
Based
on
level
oxidation
C-ring,
they
classified
into
monomers,
dimers,
heterodimers.
While
based
oxygenation
or
type
residue,
can
be
categorized
mono-,
di-,
tri-,
tetra-,
penta-
hexa-oxygenated
xanthones,
bis-xanthones,
prenylated
related
xanthonolignoids,
other
miscellaneous
xanthones.
This
structural
diversity
has
made
exhibit
considerable
biological
properties
as
promising
antioxidant,
antifungal,
antimicrobial,
anticancer
agents.
Structure-activity
relationship
studies
suggest
C-1,
C-3,
C-6,
C-8
key
positions
that
activity
Furthermore,
presence
functional
groups,
such
prenyl,
hydroxyl,
glycosyl,
furan,
pyran,
at
may
contribute
spectrum
activity.
unique
scaffolds
notable
activities,
structure-activity
relationships
some
lead
molecules
were
discussed
identify
possible
drug
candidates.
Molecules,
Год журнала:
2024,
Номер
29(9), С. 1917 - 1917
Опубликована: Апрель 23, 2024
Functionalization
of
C-H
bonds
has
emerged
as
a
powerful
strategy
for
converting
inert,
nonfunctional
into
their
reactive
counterparts.
A
wide
range
bond
functionalization
reactions
become
possible
by
the
catalysis
metals,
typically
from
second
row
transition
metals.
First-row
metals
can
also
catalyze
functionalization,
and
they
have
merits
greater
earth-abundance,
lower
cost
better
environmental
friendliness
in
comparison
to
second-row
alkylation
is
particularly
important
reaction
due
its
chemical
significance
applications
natural
product
synthesis.
This
review
covers
Ni-catalyzed
using
alkyl
halides
olefins
sources.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(17), С. 3578 - 3584
Опубликована: Июнь 18, 2024
Abstract
A
copper‐catalyzed
radical‐induced
annulation‐halocyanomethylation
of
indole‐linked
1,6‐enynes
has
been
established
using
haloacetonitrile
as
radical
precursors,
enabling
the
synthesis
21
cyanomethylated
pyrrolo[1,2‐
a
]indoles
with
yields
ranging
from
42%
to
81%
and
Z
/
E
ratio
up
19:1.
Moreover,
by
adjusting
reaction
temperature,
variation
annulation‐bromobicyanomethylation
process
was
achieved,
resulting
in
production
12
bicyanomethylated
]indole
isomers
41–68%.
The
stereoisomeric
mixture
products
could
be
purified
their
pure
configurations
through
recrystallization.
proposed
mechanism
formulated
series
control
experiments.
A
one-shot
substitution
of
all
hydrogens
at
the
α,β-positions
saturated
cyclic
amines
was
achieved.
The
key
feature
this
reaction
is
sequential
involvement
intra-
and
intermolecular
redox
processes.
When
N,O-acetals
obtained
through
an
internal
process
were
treated
with
a
catalytic
amount
Zn(OTf)2
excess
benzylidene
barbiturates,
three
transformations
involving
occurred
successively
to
afford
α,β-unsaturated
lactams
in
moderate
good
chemical
yields.
The
[1,n]-hydride
migration
reactions
represent
one
of
the
most
powerful
techniques
to
functionalize
C(sp3)–H
bonds
and
rapidly
construct
molecular
complexities.
However,
their
substrates
usually
required
multiple
steps
prepare
in
advance.
Herein,
we
developed
a
gold-catalyzed
intermolecular
coupling
hydride-donor-containing
nucleophiles
(amines)
hydride-acceptor-containing
alkynes
(1,3-diynamides)
for
cascade
[1,5]-hydride
migrations.
Control
experiments
revealed
role
dichloroethane
solvent
unexpected
involvement
protonated
anilines
promoting
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1012 - 1012
Опубликована: Фев. 26, 2024
The
Sc(OTf)3-catalyzed
dearomative
[5+1]
annulations
between
readily
available
3-aminophenols
and
O-alkyl
ortho-oxybenzaldehydes
were
developed
for
synthesis
of
spiro[chromane-3,1′-cyclohexane]-2′,4′-dien-6′-ones.
“two-birds-with-one-stone”
strategy
was
disclosed
by
the
dearomatization
phenols
direct
α-C(sp3)–H
bond
functionalization
oxygen
through
cascade
condensation/[1,5]-hydride
transfer/dearomative-cyclization
process.
In
addition,
antifungal
activity
assay
derivatizations
products
conducted
to
further
enrich
utility
structure.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(14), С. 2824 - 2834
Опубликована: Янв. 1, 2024
Diversity-oriented
synthesis
of
indole-1,2-fused
1,4-benzodiazepines,
tetrahydro-β-carbolines,
and
2,2′-bis(indolyl)methanes
is
presented
by
control
reaction
sites.
Abstract
We
report
a
unique
synthetic
route
to
benzo[7]annulene
derivatives.
When
benzylidene
malonates
having
1-(N,N-dialkylamino)alkyl
group
at
the
ortho-position
are
treated
with
stoichiometric
amount
of
M(OTf)3
(M
=
Sc,
Yb,
Gd),
three
transformations
([1,4]-hydride
shift/isomerization
into
an
enamine/intramolecular
Stork
enamine
acylation)
proceed
sequentially
afford
various
derivatives
in
moderate
chemical
yields.
To
our
knowledge,
present
reaction
is
first
example
internal
redox
involving
[1,n]-hydride
shift/(n+3)-cyclization
process.
