Palladium-Catalyzed Asymmetric Acetoxylative Cyclization/Acyl Transfer Cascade of Alkyne-Tethered Malononitriles with Carboxylic Acids

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Palladium-catalyzed asymmetric intermolecular trans-acetoxypalladation/desymmetric cyclization/acyl transfer cascades of alkyne-tethered malononitriles with carboxylic acids have been demonstrated. Such a sequence enables the formation multifunctionalized nitriles bearing α-all-carbon quaternary stereocenters high degree enantiocontrol broad substrate scope. Moreover, synthetic elaborations present these molecules as promising chiral building blocks. Mechanistic studies illustrate that cascade process proceeds via key imine intermediate, and desymmetric cyclization is enantio-determining step.

Язык: Английский

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Tandem Synthesis of Polysubstituted Pyrroles via Cu(I)-Catalyzed Cyclization of Ketene N,S-Acetals with β-Ketodinitriles

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

A new approach to multifunctionalized pyrroles has been explored by the tandem cyclization of α-oxoketene-N,S-acetals with β-ketodinitriles using Cu(MeCN)4BF4 and Ag2CO3 in toluene under reflux conditions. The reaction involves C–C/C–N bond creation, is assumed proceed via enamine formation, intramolecular cyclization, rearrangement. potential methodology also demonstrated for a gram-scale as well some useful organic transformations. offers practical pathway achieve polysubstituted broad substrate scope good functional group tolerance.

Язык: Английский

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Chalcone-Mediated and unexpected rearrangement preparation of 1H-pyrazol-furo[2,3-d]pyrimidine derivatives as potent antitumor agents

Journal of Molecular Structure, Год журнала: 2025, Номер 1338, С. 142312 - 142312

Опубликована: Апрель 14, 2025

Язык: Английский

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Synthetic strategies to pyrido fused heterocycles

Journal of Chemical Sciences, Год журнала: 2025, Номер 137(2)

Опубликована: Май 17, 2025

Язык: Английский

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Six-membered ring systems: Diazines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 355 - 393

Опубликована: Янв. 1, 2024

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