Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393
Published: Jan. 1, 2024
Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393
Published: Jan. 1, 2024
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
Palladium-catalyzed asymmetric intermolecular trans-acetoxypalladation/desymmetric cyclization/acyl transfer cascades of alkyne-tethered malononitriles with carboxylic acids have been demonstrated. Such a sequence enables the formation multifunctionalized nitriles bearing α-all-carbon quaternary stereocenters high degree enantiocontrol broad substrate scope. Moreover, synthetic elaborations present these molecules as promising chiral building blocks. Mechanistic studies illustrate that cascade process proceeds via key imine intermediate, and desymmetric cyclization is enantio-determining step.
Language: Английский
Citations
0The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
A new approach to multifunctionalized pyrroles has been explored by the tandem cyclization of α-oxoketene-N,S-acetals with β-ketodinitriles using Cu(MeCN)4BF4 and Ag2CO3 in toluene under reflux conditions. The reaction involves C–C/C–N bond creation, is assumed proceed via enamine formation, intramolecular cyclization, rearrangement. potential methodology also demonstrated for a gram-scale as well some useful organic transformations. offers practical pathway achieve polysubstituted broad substrate scope good functional group tolerance.
Language: Английский
Citations
0Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1338, P. 142312 - 142312
Published: April 14, 2025
Language: Английский
Citations
0Journal of Chemical Sciences, Journal Year: 2025, Volume and Issue: 137(2)
Published: May 17, 2025
Language: Английский
Citations
0Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393
Published: Jan. 1, 2024
Citations
0