Palladium-Catalyzed Asymmetric Acetoxylative Cyclization/Acyl Transfer Cascade of Alkyne-Tethered Malononitriles with Carboxylic Acids

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Palladium-catalyzed asymmetric intermolecular trans-acetoxypalladation/desymmetric cyclization/acyl transfer cascades of alkyne-tethered malononitriles with carboxylic acids have been demonstrated. Such a sequence enables the formation multifunctionalized nitriles bearing α-all-carbon quaternary stereocenters high degree enantiocontrol broad substrate scope. Moreover, synthetic elaborations present these molecules as promising chiral building blocks. Mechanistic studies illustrate that cascade process proceeds via key imine intermediate, and desymmetric cyclization is enantio-determining step.

Language: Английский

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Tandem Synthesis of Polysubstituted Pyrroles via Cu(I)-Catalyzed Cyclization of Ketene N,S-Acetals with β-Ketodinitriles

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

A new approach to multifunctionalized pyrroles has been explored by the tandem cyclization of α-oxoketene-N,S-acetals with β-ketodinitriles using Cu(MeCN)4BF4 and Ag2CO3 in toluene under reflux conditions. The reaction involves C–C/C–N bond creation, is assumed proceed via enamine formation, intramolecular cyclization, rearrangement. potential methodology also demonstrated for a gram-scale as well some useful organic transformations. offers practical pathway achieve polysubstituted broad substrate scope good functional group tolerance.

Language: Английский

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Chalcone-Mediated and unexpected rearrangement preparation of 1H-pyrazol-furo[2,3-d]pyrimidine derivatives as potent antitumor agents

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1338, P. 142312 - 142312

Published: April 14, 2025

Language: Английский

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Synthetic strategies to pyrido fused heterocycles

Journal of Chemical Sciences, Journal Year: 2025, Volume and Issue: 137(2)

Published: May 17, 2025

Language: Английский

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Six-membered ring systems: Diazines and benzo derivatives

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393

Published: Jan. 1, 2024

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