N-Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolution for the assembly of inherently chiral macrocycles DOI Creative Commons
Zhipeng Li,

Jingyang Zhang,

Wanmeng Zhu

и другие.

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We have successfully achieved the highly enantioselective synthesis of inherently chiral macrocycles through NHC-catalyzed asymmetric esterification heterocalixaromatics.

Язык: Английский

Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes DOI Creative Commons
Jiaming Wang, Kang Lv,

Yilu Wen

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

1
Asymmetric construction of axial and planar chirality with N-heterocyclic carbene (NHC) organocatalysis DOI
Meng Zhang,

Xiaoqun Yang,

Xiaolin Peng

и другие.

Science China Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

6
Design, synthesis and Anti‐PVY activity of planar chiral thiourea derivatives incorporated with [2.2]Paracyclophane DOI

Liangzhen Shu,

Ya Lv,

Zhongyin Chen

и другие.

Pest Management Science, Год журнала: 2024, Номер 80(9), С. 4450 - 4458

Опубликована: Апрель 25, 2024

Abstract BACKGROUND Potato virus Y (PVY) is a prominent representative of plant viruses. It can inflict severe damage upon Solanaceae plants, leading to global dissemination and substantial economic losses. To discover new antiviral agents, class planar chiral thiourea molecules through the key step N ‐heterocyclic carbene‐catalyzed nitrile formation reaction was synthesized with excellent optical purities for evaluations against PVY. RESULTS The absolute configurations compounds exhibited obvious distinctions in anti‐PVY activities. Notability, compound ( S )‐ 4u remarkable curative activities PVY, half maximal effective concentration (EC 50 ) 349.3 μg mL −1 , which lower than that ningnanmycin (NNM) = 400.8 ). Additionally, EC value protective effects 146.2 superior NNM (276.4 Furthermore, mechanism‐of‐action enantiomers investigated molecular docking, defensive enzyme activity tests chlorophyll content tests. CONCLUSION Biological mechanism studies have demonstrated configuration target plays crucial role interaction PVY‐CP, enhancing defense enzymes affecting content. current study has provided significant insights into roles played by chiralities protection This paves way development novel green pesticides bearing purities. © 2024 Society Chemical Industry.

Язык: Английский

Процитировано

4
Application of Asymmetric Catalysis in Chiral Pesticide Active Molecule Synthesis DOI
Xiaoqun Yang, Shichun Jiang, Zhichao Jin

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(31), С. 17153 - 17165

Опубликована: Июль 25, 2024

The different configurations of chiral pesticides generally have significant influence on their biological activities. Chiral agrochemicals with high optical purities become a prominent topic in the research field new due to advantages including lower toxicity, higher efficiency, and reduced residue levels. However, most commercially available that possess elements are still used racemic forms. To date, asymmetric catalysis has emerged as versatile tool for enantioselective synthesis various novel pesticide active molecules. This perspective provides comprehensive overview applications diverse catalytic approaches facile preparation numerous molecules, our own outlook future development this highly direction is also presented at end review.

Язык: Английский

Процитировано

4
N-Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolution for the assembly of inherently chiral macrocycles DOI Creative Commons
Zhipeng Li,

Jingyang Zhang,

Wanmeng Zhu

и другие.

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We have successfully achieved the highly enantioselective synthesis of inherently chiral macrocycles through NHC-catalyzed asymmetric esterification heterocalixaromatics.

Язык: Английский

Процитировано

0