Application of Asymmetric Catalysis in Chiral Pesticide Active Molecule Synthesis DOI
Xiaoqun Yang, Shichun Jiang, Zhichao Jin

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(31), P. 17153 - 17165

Published: July 25, 2024

The different configurations of chiral pesticides generally have significant influence on their biological activities. Chiral agrochemicals with high optical purities become a prominent topic in the research field new due to advantages including lower toxicity, higher efficiency, and reduced residue levels. However, most commercially available that possess elements are still used racemic forms. To date, asymmetric catalysis has emerged as versatile tool for enantioselective synthesis various novel pesticide active molecules. This perspective provides comprehensive overview applications diverse catalytic approaches facile preparation numerous molecules, our own outlook future development this highly direction is also presented at end review.

Language: Английский

Design, synthesis and Anti‐PVY activity of planar chiral thiourea derivatives incorporated with [2.2]Paracyclophane DOI

Liangzhen Shu,

Ya Lv,

Zhongyin Chen

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: 80(9), P. 4450 - 4458

Published: April 25, 2024

Abstract BACKGROUND Potato virus Y (PVY) is a prominent representative of plant viruses. It can inflict severe damage upon Solanaceae plants, leading to global dissemination and substantial economic losses. To discover new antiviral agents, class planar chiral thiourea molecules through the key step N ‐heterocyclic carbene‐catalyzed nitrile formation reaction was synthesized with excellent optical purities for evaluations against PVY. RESULTS The absolute configurations compounds exhibited obvious distinctions in anti‐PVY activities. Notability, compound ( S )‐ 4u remarkable curative activities PVY, half maximal effective concentration (EC 50 ) 349.3 μg mL −1 , which lower than that ningnanmycin (NNM) = 400.8 ). Additionally, EC value protective effects 146.2 superior NNM (276.4 Furthermore, mechanism‐of‐action enantiomers investigated molecular docking, defensive enzyme activity tests chlorophyll content tests. CONCLUSION Biological mechanism studies have demonstrated configuration target plays crucial role interaction PVY‐CP, enhancing defense enzymes affecting content. current study has provided significant insights into roles played by chiralities protection This paves way development novel green pesticides bearing purities. © 2024 Society Chemical Industry.

Language: Английский

Citations

4
Asymmetric construction of axial and planar chirality with N-heterocyclic carbene (NHC) organocatalysis DOI
Meng Zhang,

Xiaoqun Yang,

Xiaolin Peng

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Language: Английский

Citations

4
Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes DOI Creative Commons
Jiaming Wang, Kang Lv,

Yilu Wen

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 3, 2025

Language: Английский

Citations

0
Application of Asymmetric Catalysis in Chiral Pesticide Active Molecule Synthesis DOI
Xiaoqun Yang, Shichun Jiang, Zhichao Jin

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(31), P. 17153 - 17165

Published: July 25, 2024

The different configurations of chiral pesticides generally have significant influence on their biological activities. Chiral agrochemicals with high optical purities become a prominent topic in the research field new due to advantages including lower toxicity, higher efficiency, and reduced residue levels. However, most commercially available that possess elements are still used racemic forms. To date, asymmetric catalysis has emerged as versatile tool for enantioselective synthesis various novel pesticide active molecules. This perspective provides comprehensive overview applications diverse catalytic approaches facile preparation numerous molecules, our own outlook future development this highly direction is also presented at end review.

Language: Английский

Citations

3