Abstract
A
concise
and
practicable
route
to
the
synthesis
of
multisubstituted
2‐pyridones
via
a
four‐component
one‐pot
stepwise
cyclization
catalyzed
by
Cs
2
CO
3
has
been
developed.
During
this
transformation,
two
new
C‐C
bonds
C‐N
were
generated
through
an
intermolecular
condensation/aza‐Michael
reaction/intermolecular
Michael
addition/intramolecular
sequence.
The
alternative
protocol
offers
complementary
provide
series
structurally
diverse
polysubstituted
(21
examples)
in
good
excellent
yields
(52–81%)
from
easily
available
raw
materials
arylamines,
dialkyl
acetylenedicarboxylate,
1,3‐dicarbonyl
compounds,
trialkyl
orthoformate
under
mild
conditions.
It
might
opportunities
for
discovery
2‐pyridones‐containing
drugs.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
present
a
strategy
for
the
synthesis
of
triarylphosphines
via
palladium-catalyzed
C–P
cross-coupling
reactions
aryl
sulfonium
salts
with
[TBA][P(SiCl
3
)
2
].
This
work
demonstrates
Cu–NHC
(NHC
=
N-heterocyclic
carbene)
catalyzed
alkynylation
of
aryl
thianthrenium
salts
via
thiazol-2-ylidene
ligands,
achieving
a
Pd-free
Sonogashira
coupling
with
broad
substrate
compatibility
and
functional
group
tolerance.
Late-stage
pharmaceutical
rare
alkynylative
C–H
functionalization/ring-opening
pathways
are
enabled.
Thiazol-2-ylidenes,
featuring
"half-umbrella"-shaped
geometry,
exhibit
superior
catalytic
performance
over
traditional
imidazol-2-ylidenes,
underscoring
their
unique
ligand
efficacy.
catalysis
enables
the
use
as
versatile
electrophiles
for
diverse
cross-couplings
under
mild
conditions.
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
Comprehensive
Summary
Visible
light‐induced
transformation
of
CO
2
and
CS
into
value‐added
products
has
attracted
worldwide
attention
because
it
mimics
nature.
In
this
context,
although
visible‐light‐induced
direct
synthesis
dithiocarbamates
carbamates
employing
SO
as
a
C1
source
been
reported,
all
these
reactions
are
limited
to
the
preparation
S
‐alkyl
mono‐dithiocarbamates
O
mono‐carbamates.
Herein,
we
report
visible‐light
photoredox‐catalyzed
multicomponent
reaction
diazosulfonium
triflates
with
amines
or
.
Mechanistic
studies
indicate
that
diazomethyl
radicals
might
be
generated
key
intermediates,
thus
providing
direction
for
application
other
radical
acceptors.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12681 - 12692
Опубликована: Авг. 21, 2024
An
aerobic
copper-catalyzed
oxysulfonylation
of
vinylarenes
with
sodium
sulfinates
is
described.
This
protocol
features
mild
reaction
conditions,
convenient
operation,
and
broad
substrate
scope
respect
to
sulfinates.
Notably,
the
demonstrates
excellent
tolerance
functional
groups
such
as
chloro,
bromo,
ester,
cyano,
nitro
groups.
Mechanistic
investigations
indicated
that
should
undergo
radical
cascades
involving
a
sulfonyl
generated
from
sulfinate
air
terminal
oxidant,
addition
across
alkene
deliver
benzylic
radical,
subsequent
cross-coupling
air.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 11083 - 11087
Опубликована: Июль 24, 2024
A
novel
approach
for
the
acylation
of
azauracil
derivatives
with
aldehydes
has
been
developed
utilizing
sodium
decatungstate
(NaDT)
as
a
photocatalyst.
This
method
demonstrates
broad
substrate
tolerance
and
yields
moderate
to
excellent
outcomes.
Notably,
it
aligns
green
chemistry
principles
by
eliminating
oxidants,
eco-friendly
energy
sources,
offering
high
scalability
operational
simplicity.
Organic Letters,
Год журнала:
2024,
Номер
26(32), С. 6841 - 6846
Опубликована: Авг. 7, 2024
A
visible-light-induced
photocatalytic
deoxygenative
benzylation
of
quinoxalin-2-(1H)-ones
is
herein
described.
This
novel
approach
provides
a
mild,
simple,
and
practical
route
to
3-benzylquinoxalin-2(1H)-ones
from
ubiquitous
safe
carboxylic
acid
anhydrides.
wide
range
substrates
with
different
substituents
were
well-tolerated
efficiently
transformed
various
functionalized
great
potential
for
valuable
applications
in
drug
discovery.
Mechanistic
investigations
suggest
H2O
as
proton
source,
while
hydroxyl-containing
quinoxalin-2(1H)-ones
may
be
key
intermediates
the
process.
Organic Letters,
Год журнала:
2024,
Номер
26(34), С. 7155 - 7160
Опубликована: Авг. 21, 2024
Thiophosphates
serve
as
pivotal
reagents
within
the
realms
of
both
organic
and
inorganic
synthesis,
with
their
most
notable
applications
observed
in
agricultural
chemistry.
This
manuscript
delineates
a
modular
three-component
synthetic
strategy
for
site-selective
arene
C–H
thiophosphorylation
thianthrenium
salt,
1,4-diazabicyclo[2.2.2]octane-sulfur
dioxide
(DABSO),
diarylphosphine
oxides
substrates.
approach
facilitates
metal-free
green
synthesis
diverse
spectrum
S-aryl
phosphorothioates
through
functionalization
late-stage
modification
showcasing
practicality
broad
applicability.
