Recent advances in the synthesis of trifluoromethyl-containing heterocyclic compounds via trifluoromethyl building blocks
Yaopeng Liu,
Qingyu Tian,
Jin Ge
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(31), С. 6246 - 6276
Опубликована: Янв. 1, 2024
Recent
advances
in
the
preparation
of
trifluoromethyl-containing
heterocyclics
via
trifluoromethyl
building
block
strategies
over
period
from
2019
to
present
are
systematically
summarized
and
discussed.
Язык: Английский
Rhodium(III)-Catalyzed Coupling of Quinolin-8-carboxaldehydes with CF3–Imidoyl Sulfoxonium Ylides by Chelation-Assisted C(sp2)-H Bond Activation for the Synthesis of Trifluoromethyl-Substituted Enaminones
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10736 - 10747
Опубликована: Июль 18, 2024
A
rhodium(III)-catalyzed
aldehydic
C(sp
Язык: Английский
Synthesis of Spiro 3,3′-Cyclopropyl Oxindoles via Cyclopropanation of 3-Alkenyl-oxindoles with CF3-Imidoyl Sulfoxonium Ylides
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
A
catalyst
and
additive-free
[2+1]
annulation
of
3-alkenyl-oxindoles
with
CF3-imidoyl
sulfoxonium
ylides
(TFISYs)
for
the
construction
spiro
3,3'-cyclopropyl
oxindoles
has
been
achieved.
cascade
intermolecular
Micheal-addition
reaction
intramolecular
nucleophilic
substitution
sequence
might
be
involved
in
transformation,
which
afforded
a
wide
range
multisubstituted
oxindole
products
high
efficiency
diastereoselectivity.
Язык: Английский
Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Fluorine
and
nitrogen
form
a
successful
partnership
in
organic
synthesis,
medicinal
chemistry,
material
sciences.
Although
fluorine-nitrogen
chemistry
has
long
rich
history,
this
field
received
increasing
interest
made
remarkable
progress
over
the
past
two
decades,
driven
by
recent
advancements
transition
metal
organocatalysis
photochemistry.
This
review,
emphasizing
contributions
from
2015
to
2023,
aims
update
state
of
art
synthesis
applications
nitrogen-based
organofluorine
functional
molecules
chemistry.
In
dedicated
sections,
we
first
focus
on
fluorine-containing
reagents
organized
according
type
groups
attached
nitrogen,
including
N-F,
N-RF,
N-SRF,
N-ORF.
review
also
covers
nitrogen-linked
building
blocks,
catalysts,
pharmaceuticals,
agrochemicals,
underlining
these
components'
broad
applicability
growing
importance
modern
Язык: Английский
Base‐Mediated Cascade Reaction of CF3‐Imidoyl Sulfoxonium Ylides and Diimides for the Synthesis of Functionalized Amidines
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
Abstract
A
base‐mediated
cascade
reaction
of
CF
3
‐imidoyl
sulfoxonium
ylides
(TFISYs)
and
diimides
has
been
developed
for
the
preparation
functionalized
amidines.
In
transformation,
a
nucleophilic
addition
subsequent
[2,3]‐sigmatropic
rearrangement
ylide
occur
to
enable
an
intramolecular
migration
dimethyl
sulfoxide
(DMSO).
The
unexpected
result
protocol
demonstrates
chameleonic
reactivity
TFISYs.
Язык: Английский
Synthesis of N-Aryl-4-trifluoromethylthiazol-2-amines via Insertion/Annulation of Trifluoromethylimidoyl Sulfoxonium Ylides with Sodium Thiocyanate
Yuhao Ding,
Yaopeng Liu,
Jin Ge
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12255 - 12262
Опубликована: Авг. 16, 2024
An
efficient
p-TsOH-mediated
insertion
of
sodium
thiocyanate
into
trifluoromethylimidoyl
sulfoxonium
ylides
has
been
reported,
affording
annulated
N-aryl-4-trifluoromethylthiazol-2-amines
in
42–84%
yields
a
one-pot
manner.
This
protocol
encompasses
variety
with
serving
as
the
source
"S–C═N"
moiety
thiazole
ring.
The
versatile
transformations
resulting
pharmacologically
important
were
also
demonstrated.
Язык: Английский