Copper-catalysed radical cascade reaction of N-(2-oxo-2-phenylethyl) substituted 2-pyridones with styrene to access 1,6-carboannulated 2-pyridone scaffolds

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Herin, we present a DTBP-mediated 3 + 2 cycloaddition reaction between N -(2-oxo-2-phenylethyl) substituted 2-pyridones and styrene; this can afford 1,6-carboannulated 2-pyridone scaffolds with up to 79% yields.

Язык: Английский

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Condensation of carboxylic acids with amines using the Boc₂O/DMAP system under solvent-free conditions

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We have developed an efficient solvent-free protocol for amide bond formation using Boc 2 O/DMAP, involving the in situ generation of a mixed anhydride and proceeding via sequential mechanism.

Язык: Английский

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Radical-mediated sulfonylation relay of alkyl alkynes/alkenes and electron-deficient alkenes to access vinyl and alkyl sulfones

Organic Chemistry Frontiers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A radical-mediated sulfonylation relay of alkyl alkynes/alkenes with electron-deficient alkenes using Na 2 S O 4 as a linker is developed to synthesize highly selective ( Z )-vinyl and sulfones under metal-free catalyzed system.

Язык: Английский

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Photoinduced Palladium-Catalyzed Radical Heck-Type Coupling of Cyclobutanone Oxime Esters with Vinyl Arenes

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(10), С. 7243 - 7254

Опубликована: Май 2, 2024

A palladium-catalyzed radical Heck-type coupling reaction of cyclobutanone oxime esters with olefins under visible-light irradiation has been developed. The cyanoalkyl/Pd(I) hybrid species generated by selected ring-opening C–C bond cleavage imino/Pd(I) reacted smoothly vinyl arenes, delivering the cyanoalkylation mild conditions. This elegant strategy a broad scope and functional group tolerance. Subsequently, late-stage functionalization bioactive molecules synthetic transformations product further confirm practicality.

Язык: Английский

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Recent advances in radical cascade reaction for constructing nitrogen heterocycles using azides as radical acceptors

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(27), С. 5511 - 5523

Опубликована: Янв. 1, 2024

The research advances in radical tandem cyclization for constructing nitrogen heterocycles which azide functions as a acceptor are reviewed.

Язык: Английский

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Iron-Catalyzed Perfluoroalkylarylation of Styrenes with Arenes and Alkyl Iodides Enabled by Halogen Atom Transfer

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

A new iron-catalyzed three-component perfluoroalkylarylation of styrenes with alkyl halides and arenes has been established. Alkyl undergo halogen atom transfer methyl radicals to form in reactions initiated by a combination

Язык: Английский

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Electrophotocatalytic Thiocyanation and Sulfonylation Cyclization of Unactivated Alkenes

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

We report an electrophotocatalytic process that enables the thiocyanation and sulfonylation/cyclization of alkenes. It is applicable to a wide range unactivated alkenes, using inexpensive photocatalyst 2,4,6-triphenylpyrylium tetrafluoroborate (TPPT) produce diverse array heterocycles containing sulfonyl thiocyano groups with good functional group tolerance. The protocol operates under mild, chemical oxidant- transition-metal-free, broad scope substrates. Preliminary mechanistic studies suggest reaction involves combination electrolysis reductive quenching photocatalytic cycle TPPT.

Язык: Английский

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Na₂CO₃-Promoted Synthesis of Thiocarbamates from Isocyanates and Thiols under Mild Conditions

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(31), С. 6277 - 6281

Опубликована: Янв. 1, 2024

A method for the synthesis of thiocarbamates catalyzed by Na 2 CO 3 from isocyanates and thiols was developed, possible mechanism proposed. This has advantages high yield, good tolerance, atom economy mild conditions.

Язык: Английский

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One-pot synthesis of functionalized dihydropyridin-2-ones via carbene-catalyzed base-controlled [3+3] annulation reaction

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Herein, we have described a novel organocatalytic approach to access biologically important dihydropyridin-2-ones in one-pot way with generally high yields (up 99%) and excellent enantioselectivities 99% ee). This reaction proceeded

Язык: Английский

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Synthesis of benzosultams via Ag(I)-catalyzed alkylative cyclization of vinyl sulfonamides

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A simple methodology for the synthesis of benzo-fused-γ-sultams via decarboxylative alkylation and cyclization vinyl sulfonamides is described. Carboxylic acids with diverse structural features were employed as alkyl sources in this method.

Язык: Английский

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