Organic Letters,
Год журнала:
2024,
Номер
26(49), С. 10548 - 10552
Опубликована: Ноя. 28, 2024
A
Pd/norbornene-mediated
three-component
modular
one-step
reaction
facilitated
by
dual
C-H
bond
activation
and
cascade
cyclization
is
reported.
This
procedure
uses
norbornene
as
a
catalyst
in
the
Catellani-type
an
alkylating
building
block
to
accomplish
unactivated
functionalization
protocol,
which
results
production
of
polyheterocyclic
eight-membered
sulfoximines
with
indene-fused
moiety.
mild,
scalable
protocol's
wide
substrate
range
makes
it
ideal
for
site-selective
at
highly
chemoselective
aryl
sites.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
have
developed
an
efficient
solvent-free
protocol
for
amide
bond
formation
using
Boc
2
O/DMAP,
involving
the
in
situ
generation
of
a
mixed
anhydride
and
proceeding
via
sequential
mechanism.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(10), С. 7243 - 7254
Опубликована: Май 2, 2024
A
palladium-catalyzed
radical
Heck-type
coupling
reaction
of
cyclobutanone
oxime
esters
with
olefins
under
visible-light
irradiation
has
been
developed.
The
cyanoalkyl/Pd(I)
hybrid
species
generated
by
selected
ring-opening
C–C
bond
cleavage
imino/Pd(I)
reacted
smoothly
vinyl
arenes,
delivering
the
cyanoalkylation
mild
conditions.
This
elegant
strategy
a
broad
scope
and
functional
group
tolerance.
Subsequently,
late-stage
functionalization
bioactive
molecules
synthetic
transformations
product
further
confirm
practicality.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Herin,
we
present
a
DTBP-mediated
3
+
2
cycloaddition
reaction
between
N
-(2-oxo-2-phenylethyl)
substituted
2-pyridones
and
styrene;
this
can
afford
1,6-carboannulated
2-pyridone
scaffolds
with
up
to
79%
yields.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
radical-mediated
sulfonylation
relay
of
alkyl
alkynes/alkenes
with
electron-deficient
alkenes
using
Na
2
S
O
4
as
a
linker
is
developed
to
synthesize
highly
selective
(
Z
)-vinyl
and
sulfones
under
metal-free
catalyzed
system.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
We
report
an
electrophotocatalytic
process
that
enables
the
thiocyanation
and
sulfonylation/cyclization
of
alkenes.
It
is
applicable
to
a
wide
range
unactivated
alkenes,
using
inexpensive
photocatalyst
2,4,6-triphenylpyrylium
tetrafluoroborate
(TPPT)
produce
diverse
array
heterocycles
containing
sulfonyl
thiocyano
groups
with
good
functional
group
tolerance.
The
protocol
operates
under
mild,
chemical
oxidant-
transition-metal-free,
broad
scope
substrates.
Preliminary
mechanistic
studies
suggest
reaction
involves
combination
electrolysis
reductive
quenching
photocatalytic
cycle
TPPT.
A
new
iron-catalyzed
three-component
perfluoroalkylarylation
of
styrenes
with
alkyl
halides
and
arenes
has
been
established.
Alkyl
undergo
halogen
atom
transfer
methyl
radicals
to
form
in
reactions
initiated
by
a
combination
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(31), С. 6277 - 6281
Опубликована: Янв. 1, 2024
A
method
for
the
synthesis
of
thiocarbamates
catalyzed
by
Na
2
CO
3
from
isocyanates
and
thiols
was
developed,
possible
mechanism
proposed.
This
has
advantages
high
yield,
good
tolerance,
atom
economy
mild
conditions.
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Herein,
we
have
described
a
novel
organocatalytic
approach
to
access
biologically
important
dihydropyridin-2-ones
in
one-pot
way
with
generally
high
yields
(up
99%)
and
excellent
enantioselectivities
99%
ee).
This
reaction
proceeded
