Synthesis of 6/5/3-Fused Tricyclic Scaffolds via Multistep Cascade Cyclization of α-Aryl Vinylsulfoniums with para-Quinamines and para-Quinols

Organic Letters, Год журнала: 2024, Номер 26(28), С. 5905 - 5910

Опубликована: Июль 9, 2024

Herein, we present a straightforward approach to access hydroindoline-5-one-based 6/5/3-fused polycyclic ring structures through multistep cascade reactions involving α-aryl vinylsulfoniums and

Язык: Английский

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Synthesis of Benzopyrone-Fused Hydrobenzo[c,d]indoles via Cascade Annulation of p-Quinamines and 3-Formylchromones

Organic Letters, Год журнала: 2024, Номер 26(33), С. 7031 - 7036

Опубликована: Авг. 12, 2024

A 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed cascade annulation reaction between

Язык: Английский

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Divergent Synthesis of Multisubstituted Hydroindole Derivatives via [3 + 2] Annulations of p‐Quinamines with Nitroalkenes

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(22), С. 4654 - 4660

Опубликована: Авг. 27, 2024

Abstract The synthesis of two stereoisomers hydroindole derivatives was achieved through [3+2] annulations p ‐quinamines with nitroalkenes. Catalyst‐free or in the presence DMAP, annulation reactions were employed to produce target products containing four contiguous stereogenic centers. This method enables efficient construction multisubstituted and functionalized from readily accessible building blocks reagents. Furthermore, anti‐inflammatory activity some resulting hydroindoles evaluated, three derivative showing effective inhibition NLRP3 inflammasome activation.

Язык: Английский

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One-Pot Synthesis of Chiral Spiro-Imidazolidinone Cyclohexenones

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 22, 2024

We have developed a simple and straightforward synthesis of chiral

Язык: Английский

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