Direct Multicomponent Synthesis of 3-Arylated Pyrroles Under Catalyst-Free Conditions DOI
Indresh Kumar, Amol Prakash Pawar,

Reena Jangir

и другие.

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Abstract An operationally simple catalyst-free protocol for the direct regiospecific synthesis of C3-arylated/alkenylated pyrroles has been developed. The enamine-intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before Paal–Knorr reaction multicomponent ‘just-mix’ to furnish good yields. Several C3-substituted N-alkylpyrroles have prepared under open-flask conditions, avoiding protection-deprotection chemistry.

Язык: Английский

Enantioselective Synthesis of Spiro[cyclopentane-1,3′-oxindole] Scaffolds with Five Consecutive Stereocenters DOI

Qiliang Luo,

Tao Mao,

Yao Luo

и другие.

Organic Letters, Год журнала: 2024, Номер 26(30), С. 6402 - 6406

Опубликована: Июль 22, 2024

A highly diastereo- and enantioselective cascade annulation reaction of Morita-Baylis-Hillman (MBH) maleimides isatins with

Язык: Английский

Процитировано

3

Construction of Chiral Spiro-Bridged Rings with Four Consecutive Stereocenters via Dearomative Diels–Alder Reactions of Anthracenes DOI

Gaofei Yang,

Longqing Yang, Zhenzhong Liu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

A highly diastereo- and enantioselective dearomative Diels-Alder reaction was accomplished by chiral N,N'-dioxide/Mg(II) complex catalyst. Various anthracene derivatives methyleneindolinones efficiently transformed into the corresponding spiro-bridged cyclic products with four consecutive stereocenters in good yields, excellent dr er values under mild conditions (46 examples, up to 99% yield, >19:1 dr, >99:1 er). Gram-scale synthesis of their further transformations were feasible. On basis theoretical calculation, possible working modes provided understand origin stereoselectivity this transformation.

Язык: Английский

Процитировано

0

Direct Multicomponent Synthesis of 3-Arylated Pyrroles Under Catalyst-Free Conditions DOI
Indresh Kumar, Amol Prakash Pawar,

Reena Jangir

и другие.

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Abstract An operationally simple catalyst-free protocol for the direct regiospecific synthesis of C3-arylated/alkenylated pyrroles has been developed. The enamine-intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before Paal–Knorr reaction multicomponent ‘just-mix’ to furnish good yields. Several C3-substituted N-alkylpyrroles have prepared under open-flask conditions, avoiding protection-deprotection chemistry.

Язык: Английский

Процитировано

0