Enantioselective Synthesis of Spiro[cyclopentane-1,3′-oxindole] Scaffolds with Five Consecutive Stereocenters
Qiliang Luo,
Tao Mao,
Yao Luo
и другие.
Organic Letters,
Год журнала:
2024,
Номер
26(30), С. 6402 - 6406
Опубликована: Июль 22, 2024
A
highly
diastereo-
and
enantioselective
cascade
annulation
reaction
of
Morita-Baylis-Hillman
(MBH)
maleimides
isatins
with
Язык: Английский
Construction of Chiral Spiro-Bridged Rings with Four Consecutive Stereocenters via Dearomative Diels–Alder Reactions of Anthracenes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
A
highly
diastereo-
and
enantioselective
dearomative
Diels-Alder
reaction
was
accomplished
by
chiral
N,N'-dioxide/Mg(II)
complex
catalyst.
Various
anthracene
derivatives
methyleneindolinones
efficiently
transformed
into
the
corresponding
spiro-bridged
cyclic
products
with
four
consecutive
stereocenters
in
good
yields,
excellent
dr
er
values
under
mild
conditions
(46
examples,
up
to
99%
yield,
>19:1
dr,
>99:1
er).
Gram-scale
synthesis
of
their
further
transformations
were
feasible.
On
basis
theoretical
calculation,
possible
working
modes
provided
understand
origin
stereoselectivity
this
transformation.
Язык: Английский
Direct Multicomponent Synthesis of 3-Arylated Pyrroles Under Catalyst-Free Conditions
Synthesis,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 5, 2024
Abstract
An
operationally
simple
catalyst-free
protocol
for
the
direct
regiospecific
synthesis
of
C3-arylated/alkenylated
pyrroles
has
been
developed.
The
enamine-intermediate,
in
situ
generated
from
succinaldehyde
and
a
primary
amine,
was
trapped
with
activated
carbonyls
before
Paal–Knorr
reaction
multicomponent
‘just-mix’
to
furnish
good
yields.
Several
C3-substituted
N-alkylpyrroles
have
prepared
under
open-flask
conditions,
avoiding
protection-deprotection
chemistry.
Язык: Английский