Asymmetric Catalytic (3 + 2) Cyclization and Sequential Reaction to Construct Dihydrofuran- and Azepine-Based Spirooxindoles

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

The enantioselective formal (3 + 2) cyclization and sequential reaction of 2-malononitrile-substituted oxindoles with benzaldehydes ortho-aminobenzaldehydes were achieved by chiral N,N′-dioxide/metal complex Lewis acid catalysts. This protocol supplies facile efficient access to highly functionalized dihydrofuran- azepine-based spirooxindoles. Based on the control experiments deuterium labeling studies, interconversion diastereomeric intermediates under conditions reversible 1,5-H transfer step disclosed.

Язык: Английский

Catalytic Enantioselective Functionalization of Maleimides: An Update

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(24), С. 3605 - 3622

Опубликована: Ноя. 13, 2024

Comprehensive Summary Maleimide derivatives are well‐established reactive intermediates also found in natural products, synthetic pharmaceuticals and functional polymers. Their specific reactivity widespread applications the field of bioconjugation allowed for development highly selective functionalizations based on simple additions cycloadditions with possible control central C–N axial chirality. These multisite‐reactive scaffolds have aroused a long‐standing interest throughout scientific community more particularly as powerful electrophilic partners recently nucleophilic some transformations. The persistent these easily accessible platforms over last decade has enabled new enantioselective transformations major advancements this presented review. Key Scientists

Язык: Английский

Asymmetric catalytic concise synthesis of 3-(3-indolomethyl)-oxindoles for the construction of trigolute analogs

Chemical Communications, Год журнала: 2024, Номер 60(78), С. 10926 - 10929

Опубликована: Янв. 1, 2024

In this paper, a newly asymmetric catalytic construction of 3-(3-indolomethyl)oxindoles was developed. Taking use method as the key step, concise syntheses trigolute analogs accomplished.

Язык: Английский