Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Recent
years
have
witnessed
the
emergence
of
direct
intermolecular
C(sp
Язык: Английский
N-Heterocyclic Carbene-Catalyzed SuFEx Reactions of Fluoroalkylated Secondary Benzylic Alcohols
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
An
N-heterocyclic
carbene
(NHC)-catalyzed
SuFEx
reaction
of
fluoroalkylated
secondary
benzylic
alcohols
with
sulfonyl
fluorides
and
fluorosulfates
affords
fluorinated
sulfonates
sulfates
in
high
yields.
Язык: Английский
Activation of Carboxylic Acids by using Sulfonyl Chloride Reagent: A Simple One Pot Conversion of Carboxylic Acids to Alcohols
Organic Preparations and Procedures International,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Апрель 18, 2025
Язык: Английский
Benzene‐1,3‐disulfonyl fluoride and Benzene‐1,3,5‐trisulfonyl fluoride: Low‐Cost, Stable, and Selective Reagents for SuFEx‐Driven Deoxyazidation
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(21), С. 4470 - 4477
Опубликована: Июль 23, 2024
The
development
of
synthetic
methods
for
the
synthesis
organic
azides
is
highly
important,
given
their
critical
role
in
advancing
click
chemistry
over
last
twenty
years.
We
report
a
reagent-economical,
reliable,
and
scalable
alkyl
from
primary
secondary
alcohols.
This
robust
method
capitalizes
on
synergistic
interaction
between
Sulfur
Fluoride
Exchange
(SuFEx)
reagents-specifically,
benzene-1,3-disulfonyl
fluoride
(BDSF)
or
benzene-1,3,5-trisulfonyl
(BTSF)-and
trimethylsilyl
azide
(TMSN3).
offers
procedural
ease,
accommodates
wide
array
substrates,
enables
late-stage
functionalization.
Additionally,
we
demonstrate
protocol's
adaptability
by
validating
straightforward
one-pot
deoxyazidation-CuAAC
sequence
drug
discovery
applications.
Язык: Английский
Deoxycyanation of Alkyl Alcohols
Опубликована: Авг. 23, 2024
Cyano
groups
represent
an
important
class
of
functional
motifs
in
medicinal
chemistry
given
their
synthetic
versatility
and
capacity
to
engage
essential
interactions
with
biological
targets.
However,
the
synthesis
sterically
hindered
alkyl
nitriles
using
non-toxic
reagents
remains
challenging.
Traditional
methods
often
rely
on
toxic
cyanide
sources
suffer
from
limited
substrate
scope.
Herein,
we
report
a
photoredox
catalyzed,
metal-free
deoxycyanation
alcohols
that
allows
rapid
access
wide
array
1º,
2º,
3º
cyanides
reagents.
Язык: Английский
The First Decade of SuFEx Chemistry: Advancements in SuFEx Polymerization, Non-Canonical SuFEx Reactions, and SuFEx Radiochemistry
Synthesis,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
Abstract
This
year
marks
the
10th
anniversary
of
SuFEx
chemistry,
a
field
that
has
witnessed
significant
advancements
over
past
decade.
These
include
efficient
synthetic
strategies
toward
polymerization
via
approach
leading
to
diverse
polymers,
alongside
discovery
new
SuFExable
hubs
and
coupling
conditions.
Non-canonical
reactions,
such
as
deoxyfluorination
on-water
have
also
emerged.
Furthermore,
there
been
substantial
strides
in
radiosynthesis
[18F]
hubs.
review
provides
an
overview
these
developments,
focusing
on
polymerization,
non-canonical
reaction,
radiochemistry
chemistry.
1
Introduction
2
Polymerization
3
Non-Canonical
Reactions
4
Fluorine-18
Radiochemistry
5
Conclusions
Outlook
Язык: Английский