Probing Diazo Compounds for Electro-Cascade Thiolation/Cyclization/Reduction Sequence DOI Creative Commons
Pankaj Chauhan, Jaswant Kumar, Deepak Sharma

и другие.

Опубликована: Авг. 28, 2024

Diazo compounds have extensively been investigated under light or metal-mediated conditions to carry out carbene-mediated transformations. In the search for novel reactivity, investigating these dinitrogen substrates electrochemical remained underexplored. Herein, we explored diazo establish a cascade sequence of thiolation/cyclization/reduction reactions. Electrolyzing styryl imides and aryl thiols enables direct access single diastereoisomer 2,5-pyrrolidine-dione-fused thiochromans in good yields mild metal-free conditions. Notably, tunable reactivity was achieved via S-H insertion at center slightly modified reaction Based on experimental evidences, including detection key intermediates computational studies, mechanism has also established.

Язык: Английский

Exploring Diazo Compounds for the Divergent Electro-Cascade Sequence and S–H Insertion Reaction DOI
Jaswant Kumar, Deepak Sharma, Yaseen Hussain

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

We have explored the reactivity of diazo compounds under electrochemical conditions to establish a cascade sequence thiolation/cyclization/reduction reactions. Electrolyzing styryl imides and aryl thiols enables direct access single diastereoisomer 2,5-pyrrolidine-dione-fused thiochromans in good yield mild metal-free conditions. Notably, tunable has been achieved via S–H insertion at center modified reaction Based on experimental evidences, including detection key intermediates computational studies, mechanism for also established.

Язык: Английский

Процитировано

1
Probing Diazo Compounds for Electro-Cascade Thiolation/Cyclization/Reduction Sequence DOI Creative Commons
Pankaj Chauhan, Jaswant Kumar, Deepak Sharma

и другие.

Опубликована: Авг. 28, 2024

Diazo compounds have extensively been investigated under light or metal-mediated conditions to carry out carbene-mediated transformations. In the search for novel reactivity, investigating these dinitrogen substrates electrochemical remained underexplored. Herein, we explored diazo establish a cascade sequence of thiolation/cyclization/reduction reactions. Electrolyzing styryl imides and aryl thiols enables direct access single diastereoisomer 2,5-pyrrolidine-dione-fused thiochromans in good yields mild metal-free conditions. Notably, tunable reactivity was achieved via S-H insertion at center slightly modified reaction Based on experimental evidences, including detection key intermediates computational studies, mechanism has also established.

Язык: Английский

Процитировано

2