Cu-Catalyzed biheterocyclization along with sulfonyl remote migration: Access to Marinoquinoline alkaloids and 4-sulfonyl pyrrolo[2,3-c]quinolines

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110915 - 110915

Опубликована: Фев. 1, 2025

Язык: Английский

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Unlocking Isonitrile Insertion with N-Centered Radicals: A General Synthetic Strategy toward Quinazolinone Alkaloids by Synergistic Photo/Copper Catalysis

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 5307 - 5317

Опубликована: Март 16, 2025

Язык: Английский

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Fe-Catalyzed Radical Trifluoromethylation and Cyclization of Ortho-Vinyl Enaminones with 1-(Trifluoromethyl)-1,3-benzo-[d][1,2]iodaoxol-3(1H)-one to Construct Functionalized Quinolines

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Herein, we present a protocol for the construction of functionalized quinolines, i.e., 3-acyl-4-(2,2,2-trifluoro-ethyl)quinolines (ATFQLs) 4, from ortho-vinyl enaminones and 1-(trifluoromethyl)-1,3-benzo-[d][1,2]-iodaoxol-3(1H)-one, which was catalyzed by FeCp2 promoted FeCl3 (Lewis acid) additives in solvents (i.e., acetonitrile toluene). This strategy first utilized FeCp2-catalyzed functionalization alkenes with trifluoromethyl radicals. The intermediate formed captured ortho-iodobenzoate substrate, yielding 3, then underwent FeCl3-catalyzed elimination at higher temperature to form an α,β-unsaturated intermediate. subsequent intramolecular Michael reaction yielded final target compound 4. In summary, series ATFQLs 4 were synthesized through formation two bonds (C═C C-C).

Язык: Английский

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I2-Promoted oxidative annulation of three different amines to access diverse biheteroaryls

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

An I 2 -promoted oxidative annulation of three different amines enables the assembly nonsymmetrical 2,2′-biquinolines and related bis-azines through a [4π + 2σ] reaction.

Язык: Английский

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